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Prednisolone 40 mgs ?

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Posted 1/22/2018 9:22 AM (GMT 0)
Morning all ,

So I started 40 mg of pred last Wednesday and have been doing ok with it , but if hiccup last night but I’m putting that don’t to me thinking I was magically fully healed and eating too much !

Wanted to know how it effected you guys ? Not the side effects , the actually impact on your UC ?

By of a rollercoaster with it all at the moment 😔

Cheers in advance
Posted 1/22/2018 1:33 PM (GMT 0)
For some prednisone makes them feel in a remission-like-state (I say "like" as a true remission excludes pred usage) and we feel great. For some of us, it gets us part there but not free of flare UC symptoms, and for me that's what it did. Pred would knock down 80% of the UC flare symptoms, bringing me down from 20+ bms a day to 6 or so (better but not perfect).
Posted 1/22/2018 3:28 PM (GMT 0)
Pred will reduce symptoms, for some very much. It does absolutely nothing to heal or impose remission. Given the break form inflammation provided by pred, you body needs to heal, or you meds need to get a toehold and start controlling the inflammation, or you go right back where you were before starting Pred.

Pred by itself has no lasting effect.
Posted 1/22/2018 3:52 PM (GMT 0)

iPoop said...
For some prednisone makes them feel in a remission-like-state (I say "like" as a true remission excludes pred usage) and we feel great. For some of us, it gets us part there but not free of flare UC symptoms, and for me that's what it did. Pred would knock down 80% of the UC flare symptoms, bringing me down from 20+ bms a day to 6 or so (better but not perfect).

Cheers Ipoop

So much literature on the side effects of pred but very little about what to extually expect to happen your body and your actual UC ?

I guess that whilst you take pred you would also take for example .... salofalk granules ?

BMs are definitely down ....been on it since last Friday afternoon
Blood is up and down , some days nothing somedays a lot

Logic has escaped me though
Posted 1/22/2018 3:54 PM (GMT 0)

DBwithUC said...
Pred will reduce symptoms, for some very much. It does absolutely nothing to heal or impose remission. Given the break form inflammation provided by pred, you body needs to heal, or you meds need to get a toehold and start controlling the inflammation, or you go right back where you were before starting Pred.

Pred by itself has no lasting effect.

Cheers DB

I guess my same point here , with pred do you guys still take our other meds ?
Posted 1/22/2018 4:18 PM (GMT 0)
The desired affect of prednisone is it's immunosuppressing affect, and that's why we take it. While on Pred, it can halt our immune system's attack on our large intestine, which enables our bodies to heal. Once off of pred, the attack resumes and inflammation resumes.

Why use pred? It buys us time while our other medications are given time to work. So, always take pred in conjunction with other medications, like your salofalk granules. The goal is to use the one-two-punch of pred and salofalk together to knock out (KO) the inflammation. In a quasi-standard round, you'd be on pred a total of 2-months which is often enough. Once you taper off of the pred, you continue on the salofalk granules indefinitely as a maintenance treatment. It always takes more medications to tame UC symptoms into a remission, than it does to sustain a remission. So, salofalk is often enough as a maintenance treatment.

Of course, everyone's different in what they need to beat a flare, flares vary in severity, and what it takes to sustain a remission equally varies. Simple scenario and all for the sake of clarity.

And if you've been reading here then you know no post is complete, without mention of rectal-route mesalamine like rowasa/salofalk/pentasa retention-enemas and/or canasa suppositories. If you're not already on them, then inquire and get a prescription for them!

Post Edited (iPoop) : 1/22/2018 9:22:41 AM (GMT-7)

Posted 1/22/2018 4:38 PM (GMT 0)

iPoop said...
The desired affect of prednisone is it's immunosuppressing affect, and that's why we take it. While on Pred, it can halt our immune system's attack on our large intestine, which enables our bodies to heal. Once off of pred, the attack resumes and inflammation resumes.

Why use pred? It buys us time while our other medications are given time to work. So, always take pred in conjunction with other medications, like your salofalk granules. The goal is to use the one-two-punch of pred and salofalk together to knock out (KO) the inflammation. In a quasi-standard round, you'd be on pred a total of 2-months which is often enough. Once you taper off of the pred, you continue on the salofalk granules indefinitely as a maintenance treatment. It always takes more medications to tame UC symptoms into a remission, than it does to sustain a remission. So, salofalk is often enough as a maintenance treatment.

Of course, everyone's different in what they need to beat a flare, flares vary in severity, and what it takes to sustain a remission equally varies. Simple scenario and all for the sake of clarity.

And if you've been reading here then you know no post is complete, without mention of rectal-route mesalamine like rowasa/salofalk/pentasa retention-enemas and/or canasa suppositories. If you're not already on them, then inquire and get a prescription for them!


So if prednisone doesn’t work, is that saying your immune is overriding the pred? Or should I give it more time to halt the attack?
I was on salofalk granules and have been on pentasa suppository, I stopped them as I just assumed I was meant to whilst taking the pred, but ideally what I need to be doing is going all guns blazing on the 3 of them? Or maybe even more?
I understand what you mean, pred gets you to a place, but doesn’t take you where you need to be , hence the other medications coming into play together.
I have a check up with the IBD nurse Wednesday which will be exactly 1 week of being on pred, so I will ask what else I can take.
Posted 1/22/2018 5:43 PM (GMT 0)
What pred dose are you on? 20-40mgs would be typical.

Yes all guns a blazing as you say. Pred can take a couple weeks to fully kick in, faster if you continue taking your salofalk granules and pentasa suppository.
Posted 1/22/2018 6:32 PM (GMT 0)

iPoop said...
What pred dose are you on? 20-40mgs would be typical.

Yes all guns a blazing as you say. Pred can take a couple weeks to fully kick in, faster if you continue taking your salofalk granules and pentasa suppository.

Cheers Ipoop

I’m currently on 40 mg a day since last Wednesday afternooon , meant to be tapering down after 1 week ?

I also question this , I’m 6,6 and about 20 stone , sort of look like Sully from monsters inc , does that not come into play when someone half my size is On the same dosage ?

All guns blazing it is then !

Also thank you very much !
Posted 1/22/2018 7:10 PM (GMT 0)
Pred isn't weight-based.
Posted 1/22/2018 8:59 PM (GMT 0)
Steroids helps a lot when you are in relapse. But it will take time maybe a week or week and half. Make sure you take calcium supplements and if you develop heartburn take some PPI or something. I was started on the same dose as you and it worked amazing. The amount of times i went to the bathroom dropped by half the amount in the first week. By week 4 the blood stopped. By week 10 I had like 3 or 4 bowel movements that i could control when and where smile Just make sure you're taking calcium to protect yourself from side effects. And avoid salt.
Posted 1/22/2018 9:05 PM (GMT 0)

iPoop said...
Pred isn't weight-based.

I wish it was weight based , it might help , lol !

Thanks for your help !

It’s hard work understanding how they are meant to effect you , not in a side effects sense but in a healing / stopping sense
Posted 1/22/2018 9:11 PM (GMT 0)

Hoda said...
Steroids helps a lot when you are in relapse. But it will take time maybe a week or week and half. Make sure you take calcium supplements and if you develop heartburn take some PPI or something. I was started on the same dose as you and it worked amazing. The amount of times i went to the bathroom dropped by half the amount in the first week. By week 4 the blood stopped. By week 10 I had like 3 or 4 bowel movements that i could control when and where smile Just make sure you're taking calcium to protect yourself from side effects. And avoid salt.

Thanks Hoda , your history sounds similar to mine !

I think I expected miracles quickly and maybe need to be more realistic

I am slowly gaining more control
Posted 1/23/2018 8:58 AM (GMT 0)

Hoda said...
Steroids helps a lot when you are in relapse. But it will take time maybe a week or week and half. Make sure you take calcium supplements and if you develop heartburn take some PPI or something. I was started on the same dose as you and it worked amazing. The amount of times i went to the bathroom dropped by half the amount in the first week. By week 4 the blood stopped. By week 10 I had like 3 or 4 bowel movements that i could control when and where smile Just make sure you're taking calcium to protect yourself from side effects. And avoid salt.

Hoda how long were you on the prednisolone for ?
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