Splitting Prednisone dose

Anyone have any expierance with splitting their Predndoae throughout the day? I am currently on 40mg I take it all at 5am. However it never last all day/night bleeding starts around 8-10pm and last until my next dosage I wake up 3-5 times at night. Wondering if splitting the dose at 20/20 would help?

Increasing the amount I won’t do, it has already literally eaten my muscle as it does every time. Both times I have been placed on it I lost 25lbs mainly muscle. I won’t increase to 60mg for fear of losing even more lbs.

I usually took my dose split, half at 5 am and the other half by 2 PM. Any later and I couldn't sleep. I also still struggled in the evening, but I was always able to stay in bed (if not sleep) from 10-4:30 when flaring.

Yeah, sounds like a good idea. If it keeps you up then take it a bit earlier. Good luck man, hope that stops the bleeding.

It's worth a try, however prednisone is notorious for causing insomnia, if I took a dose late, there is no way I would have gotten any sleep.

How long have you been on 40mg?

It's tough, you have to wonder if you need to attempt different treatment options sooner than later if you're on 40mg and still having nocturnal BMs and bleeding, especially if you've been on 40mg for a period of time. If you just started it a few days ago, that's a different story.

What other meds are you taking? Have you tried enemas? Many of us use combinations of drugs to keep things at bay.

Sorry left out taking 50mg tramadol 3 x a day it doesn’t do much but does take the edge off excruciating pain during formed BMs.

Started with Apriso Nov 2013 diagnosed with UC after colonoscopy I had been flaring for several months and had no clue what was wrong with me. Placed on Humira Jan 14 immediately went into remission. Kept with meds Apriso and Humira until July 17 this current flare started and blood test showed Humira no longer was effective. Aug/Sept. placed on 40mg Prednisone and Simponi along with Apriso. Oct. taper off Prednisone gained 10lbs back Simponi was starting to work( no bleeding) still lots of mucus and urgency. Nov symptoms came back so I went back on Prednisone 40mg (lost weight again) still taking Apriso. Dec had a colonoscopy which reveled moderate/ sever UC in my sigmoid colon I was then prescribed Entyvio. Currently had 2 doses of Entyvio take Apriso and Prednisone along with Tramadol. Stools are skinny but formed and a tad painful (3 daily) Other Stuff blood/mucus is at night and early am 3-5 times. I struggled big time Aug-Oct was off work for a month and a half, was hospitalized, and had an perineal abcess removed.



I have never been prescribed Enemas I’m not opposed to any meds that may
Get me back to normal.

It sounds like your UC has gotten more severe over time which is somewhat common. You'll need more medications to stay off of the pred.

You've never tried Rowasa Mesalamine-retention enemas, I'd give them a whirl. They're 4.0 grams of anti-inflammatory Mesalamine taken nightly before bed. I would ask your gastereoenteroligist for a prescription. Our most annoying symptoms come from rectal-inflammation (painful stools, tenesmus: feeling we have to poop but nothing passes, urgency, bleeding) and that medication goes straight to the source and is effective there.

You've never tried immunomodulators (Imuran/azathioprine or 6MP) and I would ask your gasteroenterolgist if adding that to your other medications makes sense. I would think so.

Combination therapy is often the most effective treatment for controlling UC flares, and it can take the cumulative effect of a lot of medications together to put you into a remission. It takes less medications to sustain a remission than to achieve it, so you can reduce some of those once a remission is sustained.