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Potential Cure for Ulcerative Colitis

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Posted 4/18/2018 1:57 PM (GMT 0)
Hello, UCers!

“Lab rats taking Eugenol (from Clove Bud Oil) increased their inner mucosal layer by 57% in 7 days!” After several years of untreatable ulcerative colitis I started taking Clove Bud powdered capsules from Whole Foods a week ago and am well on my way to a full recovery.

Also, 10 days before Easter I was put on 40mg of prednisone. I experienced 12 hours of less blood, then it came back for several days. Slapped on a nicotine patch, and the following day the blood was gone. Still a trace here or there, but nothing like it had been. Long story short, the nicotine helped me pull it together but adding Clove Bud Oil a week ago has led to a dramatic improvement.

My daily routine is currently: a whey protein shake (high in l-glutamine) with acacia fiber (the soluble fiber gel it creates is very soothing to your colon), butyrate, clove bud powdered capsules, a probiotic, and a banana to help push the pills down. I enjoy this as a first or second meal, on a fairly empty stomach. In the evening, I repeat this as a final meal ideally, again on a fairly empty stomach.

I’ve always enjoyed IHAVEUC and Healing Well but never joined your respective communities. I have a strong feeling that Clove Bud Oil (and possibly nicotine therapy) will put a lot of you into remission, or at the very least make life a lot more enjoyable.

Here are links to a few studies:

1)Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271691/?report=classic

2)However only eugenol stimulated production of the inner mucus layer, a key mucosal barrier to microbes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365398/

3)Nicotine or agents that have similar effects on colonic mucosa may emerge as useful therapeutic agents for colitis: http://www.nejm.org/doi/full/10.1056/NEJM199403243301202

To sum up: butyrate provides energy to Goblet cells which then use Eugenol from Clove Bud Oil to increase thickness of the inner mucosal layer...

Cheers!, Rich

Post Edited (Judson) : 4/19/2018 12:02:38 AM (GMT-6)

Posted 4/18/2018 3:21 PM (GMT 0)
There are no cures for ulcerative colitis, so your subject is very misleading, and bit rude in all capital letters.

Glad you're feeling better, and thanks for sharing what worked for you.
Posted 4/18/2018 4:05 PM (GMT 0)
Here is my old thread, perhaps will revisit.
oldmike
/www.healingwell.com/community/default.aspx?f=38&m=3379873
Posted 4/18/2018 5:43 PM (GMT 0)
From now on try to keep in mind that throwing the word "cure" around is a great way to keep people from taking what you have to say seriously. In addition one week is not a long time to document a recovery. We can be in remission for months and experience a full out flare out of the blue. Being in remission for several months to years on a specific regimen is a far better testimonial. Stick with it and keep reporting back.
Posted 4/19/2018 2:57 AM (GMT 0)
Thank you! Staying positive goes a long way in helping us to feel better! Thank you so much for sharing! :o) I prefer not to focus on the fact there is no cure, that is very negative. Negativity and stress are triggers for sure! We can get in remission and naturally and in a very healthy way and that's amazing!! I hope it works for years! I will try it too! Thank you so much! Enjoy your life! Each day is a blessing!


"A joyful heart is good medicine, but a crushed spirit saps one's strength." (Proverbs 17:22)
Posted 4/19/2018 6:19 PM (GMT 0)
I'm all about a positive mindset, but there's a difference between being negative and being realistic. A cure is a treatment which works universally (extremely high success rate for everybody). Calling anything a cure or saying you have cured a condition which medically has none isn't positive, it's misleading. There is no cure for UC (yet) only medications and remedies that lead to remission. There's nothing inherently negative or "stressful" in that statement. It's simply a matter of choosing your words carefully.

The way I see it, not having a cure isn't a negative, it's a challenge. Challenge accepted.
Posted 4/19/2018 6:27 PM (GMT 0)
Being realistic seems to make more sense.
q
Posted 4/20/2018 7:04 AM (GMT 0)
I get supplement fatigue too. However, THIS may help a few of you. Please try. I haven't had any side effects, and it's the only thing I've tried that's worked. FYI, I'm on Entyvio, Lialda, and prednisone but it wasn't until I added these Organic Clove Bud powdered capsules from Whole Foods (and nicotine patches) that I noticed an improvement. Nicotine seemed to more or less stop the bleeding and stabilize things, but it wasn't until I added clove bud capsules 10 days later that things really took off. I've gone from 0% to 50-60% in 3 weeks after few if any signs of improvement for several years.

Post Edited (Judson) : 4/20/2018 2:35:35 AM (GMT-6)

Posted 4/20/2018 7:29 AM (GMT 0)
Maybe it was the nicotine patches that worked....

Be that as it may, glad you've found something that helps, however. Many of us find medication gets us 60% of the way better (which is better than nothing, but not great) and supplements help with the remaining 40% (although rarely all 40%).
Posted 4/20/2018 8:08 AM (GMT 0)
Thanks FSLondon, if a few open minded UCers try clove bud capsules it will spread. I've tried 12s of supplements and they're the only one where I've noticed a substantial improvement in a short period which is why I'm pounding the table. But yes, there may be some synergy. Lialda (mesalamine) is probably one of the weaker meds but most of my doctors swear by it.

My Dr. put me on prednisone 10 days before Easter. Less blood for 12 hours. Blood came back for a few days. Went on the patch the Saturday b/f Easter, ever since blood has become much less frequent. Things stabilized. I was feeling good enough to play with my nieces and nephew over Easter. However, when I took clove bud capsules a week later my improvement really took off.

Post Edited (Judson) : 4/20/2018 2:21:33 AM (GMT-6)

Posted 4/20/2018 12:27 PM (GMT 0)
How long were you on Entyvio, before clover buds were tried? As you do know it takes 12-14 weeks for entyvio to kick in with some of us....
Posted 4/20/2018 2:55 PM (GMT 0)

FSLondon said...
Many of us find medication gets us 60% of the way better (which is better than nothing, but not great) and supplements help with the remaining 40% (although rarely all 40%).

I guess that makes me one of the "rare" cases that have achieved remission with alternatives and not meds, far more than 40%. However people "rarely" try what I've tried. My alternative was so powerful that I stopped taking meds, it was incredibly fast acting to stop the bleeding I've endured for years and haven't seen since. The only remaining symptoms are occassional aching in the rectum.

The die hard med people (most who aren't even close to remission) implore me to cave in and take meds to deal with the remaining symptoms. I never appreciated the side effects of meds, and I'm still convinced that if I can achieve such a high level of remission with a single alternative then there are ways to deal with the remaining symptoms without meds. It's a challenge and it only starts with a willingness to try new things.

Maybe clove bud will help with the last 5% of my symptoms (calm down, calm down, I'm actually going to try it, unlike the majority of people reading). I've heard of clove bud oil before, just never got around to ordering it. Nicotine however did not make a significant difference for me, whether patch, gum or vaping. Perhaps there's something magical about this combination, perhaps it's your biology.

However, I've acheived 95% remission with a single alternative supplement, you are still on medication. You're urging people on to try your alternative, but are you willing to try mine? I'm willing to try yours...

Pounding the table feeling like people aren't listening to your solutions? Welcome to the party.


PS: As always I'm not advising people to stop their meds, just telling my story.
Posted 4/20/2018 3:42 PM (GMT 0)
I've heard of clove oil as well. And saw the mouse studies, which are very interesting. I've been afraid to try it because of its liver toxicity. Thoughts on whether eating ground cloves in other food would be effective?

Also, I've had good success with SCD plus what I'm now calling the modified Canada Mark model (turmeric, WOO and black pepper+probiotics) so am fairly happy with that combo for the time being. Will keep thinking about and reading about the clove oil option.
Posted 4/20/2018 5:02 PM (GMT 0)
Judson, thanks for sharing this! Very interesting hypothesis and I appreciate your candid account of your own success with the clove oil -- I really hope that continues! After reading this I bought some clove oil tincture from the local health food store and have been adding 10-15 drops to a cup of water 2x per day. So far I too am liking the results!

I'm on Remicade, Imuran, and Colozal -- largely stable on those three for about 20+ months at this point. No medically-recognized flare up since then (with normal calprotectin tests done quarterly to confirm), though I do occasionally have my "off weeks" that I fear may be early signs of something brewing. Whether very mild IBD or annoying IBS, I hate the feeling when that strikes (looser stool, less appetite, sometimes very mild upset stomach), and have been extremely motivated to get rid of it and keep it away.

With that in mind, my GI and I both try our best to stay up to date on the latest research, whether it be around meds or supplements. I missed this one, though, and am glad that you brought it to our attention. I was having one of those "IBS" episodes about a week ago (in quotes because I'm not 100% sure what was going on), but within a few days on the clove oil it appears to be much improved as of the last 2 days. Appetite is back, stools normal, and I'm feeling much more confident about this remission again. Of course no one can be certain that the improvement has anything to do with the clove oil, really, but it seems like a very convenient sort of coincidence if nothing else!

I hate declaring any wins against UC, big or small, because we all know how unpredictable it can be... and I don't want to jinx anything. With that said, I've felt enough benefit over just a few days to consider this supplement a good one to have on hand. I'm planning to continue it for a while and will try to check in with any news -- please do the same if any of you try it (or other meds or supplements)!
Posted 4/22/2018 4:47 AM (GMT 0)
Group shout out! Not in order but hopefully everyone. This will be a one-two punch w/ a second post forthcoming. 1)iPoop, I'll have been on Entyvio for 1 year as of this June. I noticed a bump or two but things spun pretty badly out of control a few months ago. 2) Eekseel hopefully a few regulars will try, it will work and spread. Not on here to piss people off, but it would be super selfish not to pass along. I'm busy too but... 3) FSLondon way to go on the SCD, hated it. 4) HJ Quinn good luck, and keep me posted! Please see my next post, replied to Sin Miedo a few minutes ago. Doing my best to explain my situation accurately, takes a few tries. I'm on Butyrate (from Amazon) + Clove Bud capsules (from Whole Foods). Had been on butyrate for months prior to clove bud capsules, when I added the capsules BOOM! 5) Thanks, Rocket Man. Have a condensed version that finally makes sense I passed along to my pharmacists, need to resend to my dr. Would reserve nicotine patches for former smokers and super desperate people like me. Wish I'd learned about the eugenol/clove buds first. Will taper off the nicotine in a few months, hopefully clove buds are enough. FYI it wasn't until I started the cb capsules that I noticed the BIG improvement. Maintaining around 50% of normal for a week or so. Enough of an improvement to be happy and have energy again. Thanks, I'll copy and paste the other in a sec. Hopefully it will be more to go on, takes time to figure out how to explain...
Posted 4/22/2018 4:49 AM (GMT 0)
Sin Miedo (w/0 fear), I like it. Appreciate the thoughtful response. As with the majority of members, I'm on a host of meds including Entyvio, Lialda and Prednisone.

I was familiar with the smoking study a few years ago and tried smoking. Couldn't handle it, tried a patch here or there (NOT CONSISTENTLY) and gave up.

Was put on prednisone 10 days before Easter (no results w/ Entyvio and Lialda), bm with little blood 12 hours later, then problems again for a few days.

Tried 14 mg patches the Sat before Easter, blood cleared up immediately (maybe a little here or there, but not noticeable) and things stabilized. Was healthy enough to play w/ my sister's kids over Easter.

Not being wild about nicotine, I walked into Whole Foods 7-10 days later looking for a natural alternative to nicotine. Mentioned Eugenol, and came away with organic clove bud (powdered) capsules.

Long story short, noticed an immediate difference and continued to improve. I'm currently around 50% + (had been @ 0%) and maintaining after a quick ramp up (I had been about to quit work and now am well enough to be happy and enjoy life).

Wish I'd found clove buds before nicotine. Butyrate (from Amazon) to provide energy to Goblet cells which use Eugenol (clove bud capsules [from Whole Foods]) to repair our inner mucusal lining).

I'd love to hear from someone who takes butyrate and clove bud capsules CONSISTENTLY without the nicotine patches. Will stay on nicotine patches for at least a few months, nicotine also stimulates mucus (smokers don't have UC, former smokers and non-smokers do), then taper to butyrate and clove bud capsules only.

Come on, guinea pigs lets go!
Posted 4/22/2018 4:59 AM (GMT 0)
I agree with eekseel. I'm also in remission without meds. And to clarify from my post on qing dai, I'm not saying natural remedies have no side effects at all, but I am saying that I'm personally experiencing no side effects from qing dai. Hallelujah!

I realize some may be sensitive to the word "cure". I am realistic about it, it's not a negative statement but it's negative to dwell on it. I think it was starting to sound more negative to me because it seems to keep coming up. I've seen people on this forum who were honestly searching for relief told that they're in denial, under treating or rude when that isn't their intent. I think it just hurts my heart a little bit. I think everyone means well but ultimately we all have a right to choose what we put or not put in our body. It kinda feels like there are a few party poopers that like to go around poopin on people's parade. Just sayin... :oD I'm not saying anything else about it because that's not what I came here for. I'm so grateful for the positive and negative experiences that have been shared here because we can learn so much from each other. Who is more invested in finding relief than us?

So excited about cloves! I've been taking fiber supplements which I think produces butyrate so hopefully I'm getting enough butyrate. So much research I'm cross-eyed. Good night for now. :o)

Post Edited (HJQuinn) : 4/21/2018 11:10:00 PM (GMT-6)

Posted 4/22/2018 5:33 AM (GMT 0)
Thanks, HJ I needed that! I changed to "potential cure" but I understand both sides. Personally, I wouldn't click on a supplement subject heading at this point. Got to get people's attention. My current position is that our meds ARE NOT restoring the mucus in our colons (THAT IS WHERE WE NEED TO FOCUS OUR RESEARCH).

Those of us who are still sick, probably have 1/2 as much mucus as a healthy person in our inner mucosal lining. Maybe I'm at 75% now, sure hope it continues. I also use acacia fiber (soluble, good for colon) and whey protein (glutamine, good for digestive tract) to wash down the butyrate and cb capsules sometimes.

Traditional Chinese Medicine is amazing, have bookmarked QD to read later. I also included a TCM link that mentions butyrate in my original post (rat study may link butyrate and eugenol as well). A number of TCMs mentioned helped, but it wasn't until I added the cb capsules that almost normal bms started to make their first appearance in 1 1/2 years (I had a 3 mo remission in the middle of a more or less continuous 3 year flare). Good times!

There's a definite mind-body link for most of us. I outgrew my serious, brooding personality long ago. My UC stems, I believe, from pounding a pot (or two) of coffee on a sometimes empty stomach while running a "celebrity" black car service for 10 years. There's zero history in my family. First you loose milk, then cheese. Before long, your body thinks everything you put in your mouth is the enemy.

Positivity goes a long way, luckily I'm in a good place mentally so I'm not fighting that as well. Nightmare disease, hope I can join you among the healthy in a few weeks or months!

Oh yeah, if you were sick for a while I'm assuming you had a lot of scar tissue. Does that go away eventually?
Posted 4/22/2018 9:52 AM (GMT 0)
Interesting. I've got both cloves and clove oil in the house. What's in your capsules - is it just powdered clove bud - and how much are you taking?
Posted 4/22/2018 10:45 AM (GMT 0)
Judson: I believe you are on the right track, I should have quite a few mucus threads, just search mucus oldmike. Lots of stuff goes on, with normal mucus the bacteria cannot penetrate, but with us it has lower viscosity and dimensional thickness,with crohns the mucus is too thick where it does not flow to flush the bacteria from crypts. Protease is also a problem either from bacteria or our own not being deactivated,then we also run out of antitrypsin to deactivate protease. We also have goblet cell depletion, both depleted of mucus and of numbers of cells. Once the immune activation starts all hell breaks loose.
The we have an interesting fact to key on, why dose in most cases UC start in the rectum. Possibles are low blood flow, least amount of mucus,high bacteria load,possible high bacteria protease load. I could go on and on, but this give more food for thought. Oh yea whey protein does help if you can handle it. It supplies the amino acids necessary to make mucus proteins. Keep at it, I am on year 38 of research, with little to show. I can't even 100% rule out that UC is contagious, though probably genetic, but perhaps a small component, then we have epigenetics.
Like I said I was eating cloves back in 2015 when I first found the work, but never got around to getting
ground clove capsules, I guess I have hundred of bottles of stuff that does not work. Perhaps I did not take enough. Since the mouse study used low concentrations of eugenol in drinking water I was hoping low concentrations would work.
oldmike

Post Edited (Old Mike) : 4/22/2018 4:56:43 AM (GMT-6)

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