Is there a relationship between Colitis and Prostate PSA count ??

Hi Joel, welcome to the forum.....I've not heard that before...but I'm sure you could do a search to find some information.

It's possible that some increases can coincide with others...

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I do know you can raise your PSA by getting a digital exam before the blood draw. Sex the same day can throw it off. A infected or inflamed prostate will throw it off big time. It is so close to the wall of the rectum it would seem reasonable that UC could cause a high PSA. It also goes up with age.

I am not big on the test anymore even though there is aggressive prostate cancer in the family.

I would seem likely that a country like Sweden that is big on medical records would be able to generate data on high PSA and UC.

Just to clarify that I am talking about a trend of rising PSA over the years and borderline high pca-3. But Biopsy and MRI (using Endorectal coil and 3T machine) of prostrate came out clean. Yes, there could be many reasons for PSA going up but we (urologist, GI specialist, and I) are not able to put a finger on the reason why. And these are top notch docs from top 10 institution in the country! More biopsies are an option but we are opting for careful wait and watch in light of super clean MRI and negative first Biopsy. Can't help but think that there might be some connection between UC and prostrate cells generation.

I have been on this roller coaster of a ride with my psa rising and trying to hold off on a biopsy. This has been going on for about 2 years now. I have lower left uc and proctitis which I manage with lialda and canasa. I am in remission now but had figured out that my proctitis was extremely low in the rectum and while I was taking my canasa nightly at bedtime I could not stop the bleeding. This went on for a year until I thought that maybe the canasa is not getting low enough in the rectum. I then thought maybe I can try taking it in the early evening while still on my feet which would keep the canasa lower. Would you know this work immediately. The problem is that In the past I had used the canasa on a as needed because it was expensive for me.

It will be 2 years this september when I started using canasa nightly. I had started it nightly at that time because I was scheduled for a colonoscopy that novemver and really wanted to have good results. The problem with my psa started in accordance with my use of the canasa daily. As a matter if fact I cant take it daily now because my body just does like it. Last winter I thought I had a urinary track infection and went to the emergency room and they had given me antibiotics but the urine test found nothing. I had discomfort while urinating and my crotch area ( seat) area was aching. I had told my gastro and he told me to back off the canasa and sure enough the symptoms of a urinary track infection went away over a few weeks time. Ot would indicate that too much canasa is not good for me. All this was prior to me figuring out that I had to take canasa standing up to get it to stay in the very lower rectum. I had gone back on nightly canasa and since then but has only been 2 weeks since switching to only taking my canasa every other night and things are fine uc and proctitis wise. The issue now is I believe anyways is that the canasa is the reason my psa test showed a rise to 5.8. My urologist of course wants me to get a biopsy done.

With all that said Is it fair for me to say that since I know the canasa can and has caused me urinary issues that it also can be the cause for my psa rising? I am on week 3 of every other night canasa and feel great but do notice the days I do the canasa I may dribble a tiny bit. The days I dont all us fine.

I had a 4kscore test done one year ago and it was 7. I also had a 3 t mri of the prostate which had a score of 3 which is (equivocal) in which they saw a small lesion in the transition zone. 3 meaning out of a score system from 1 to 5 3 being they were unable to say it is ir is not cancer. At that time my psa was 4.1.My urologist still of course recommended a biopsy but said it was not unreasonable to check back in 6 months. 6 months later snd still on daily canasa psa 4.8. 3 weeks ago and was still on daily canasa psa 5.8 and now 4kscore of 19. All the while he finds nothing on a dre. My recent percent free psa is 19 percent and the psa according the 4kscore test was 6.46 up from 3 weeks prior which was 5.8.

While this post is two sided and I will most likely post it also on the prostate cancer forum I would appreciate any feed back in regards to my rectal meds and proctitis and psa concern.

Thanks

Post Edited (twiggs) : 5/30/2018 8:34:44 AM (GMT-6)

I'd say you have good cause for a prostate biopsy to investigate and see exactly what is going on, and then at least you'll know a bit more about your rising PSA scores and whether there is any actual prostate cancer or whether or not it is a false alarm.

I'd wager a rising PSA score and canasa are unrelated, perhaps wishful thinking. Canasa is a 90% topical anti-inflammatory, how exactly would it impact the prostate?

PSA scores can and do bounce up and down even without making changes. Therefore it would take a series of PSA tests (perhaps 6-months or more) to notice if there is indeed a trend from your changes.

I understand your theory and the proximity of canasa to prostate, however, I just happen to disagree and think you are only delaying the inevitable; getting a biopsy. Calling it as I see it. Do as you will ;-)

I had an unnecessary prostate biopsy when all I needed was 3 weeks of an antibiotic (ciprofloxacin I believe). My psa went down to 2.8. I wish the doctor would have suggested the meds first, before the very unpleasant biopsy and it's after effects!