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Switching from adalimumab to vedolizumab

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Ulcerative Colitis
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Posted 8/28/2018 12:56 PM (GMT 0)
I currently have moderate pancolitis for only a couple weeks but things are getting rapidly worse and I'm now feeling really exhausted. Losing a lot of blood and constant diarrhoea also through the night.
The ibd team want to switch me from humira to vedolizumab sooner rather than later as they dont want me to end up in hospital again.
I just wondered if anyone else has done this switch and was ot successful? How long did it take you for things to improve? Thanks.
Posted 8/28/2018 1:07 PM (GMT 0)
Why didn’t you start on Remicade? It has a little better response rate than Humira.

Entyivio is slow working, you’ll need some additional medication to bridge that time until it kicks in.

When switching meds it is good to get tested for c.diff, just to make sure that you didn’t pick it up along the way. Especially since you are new to UC.
Posted 8/28/2018 2:02 PM (GMT 0)
I've just switched from Remicade. I developed antibodies to Remicade while doing the loading doses and possibly drug-induced lupus. Felt like I'd been beat up, everything hurt, daily frequency hit an all time high with lots of blood and gore. Now it is two months later, I've had two loading doses of Entyvio, going for #3 next week. Frequency is around 5 - 6/day but usually formed. Gut pain is mostly gone. Is it the Entyvio, the pred or just the Remicade getting out of my system? Dunno. I've also been taking psyllium seed faithfully.
Posted 8/28/2018 2:35 PM (GMT 0)
Sorry I should have given more info ks1905.
I am not new to UC ive had it 10 years but i meant this current episode has only been going on a couple weeks.
I have been on infliximab before on my last admission 3 years ago. Then switched to humira. The humira went up to weekly but im getting very rapidly worse.
I have sent a stool sample which is negative and dont have c diff.
Tired of- sorry you've neen so unwell im glad to hear you're doing better. Yes its hard to know what is having the positive effect when several meds on the go!
Posted 8/28/2018 5:37 PM (GMT 0)
You could try Cimzia, it is similar to Remicade and will work faster than Entyvio. The problem is that it still uses the same mechanism as Remicade and Humira so it may not be effective for you.

Are you using any rectal meds? They can improve your quality of life
Posted 8/29/2018 6:47 AM (GMT 0)
I switched from Humira to Entyvio; worked for me. Hard to say how quickly, because the switch was coincident with restarting hydrocortisone enemas, which as before improved my symptoms in a couple of weeks. But after 2 months I was pretty sure the Entyvio worked better, with slow improvement over the next 6 months.

I had previously had moderately severe symptoms unremittingly for over two years. Been on Entyvio since December 2016. Best treatment so far.
Posted 8/29/2018 6:50 AM (GMT 0)
Correction: been on Entyvio since December 2015 (not 2016). Time flies...
Posted 8/29/2018 4:53 PM (GMT 0)
Entyvio is very slow working, 10-14 weeks.
Posted 8/29/2018 5:57 PM (GMT 0)
Oh no really ipoop? I spoke to ibd nurse today and she said it should work in 6 weeks.
Posted 8/30/2018 4:02 PM (GMT 0)
What I've heard over the years here. Works faster for some, of course.
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