I take one glucosamine/chondroitin (500/400) daily & it does help the knee joints. For shoulder pain I'd recommend a topical, like BenGay Arthritis Formula. Try to assess whether the shoulder pain could be originating in your neck. I heard from a physical therapist that this is often the case, but patients don't realize it. Also, if your UC is flaring, the joint pain will likely persist 'til your colon calms down. / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily; seem to be back in remission)