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Medicines stop working?

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Ulcerative Colitis
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Posted 2/18/2010 1:00 PM (GMT 0)
I only ask this because my doctor is having me try Apriso and to stop taking Colazal. It has only been 2 days and I'm starting to see improvement with Apriso. When I was taking Colazal, which I've been on this entire flare up, I don't think it was doing much of anything.
Funny though, cause my doctor described Apriso as being a maintenance drug, instead of one that is to pull one out of a flare up.
So is it possible that your body can become used to an 5asa?

Hopefully though Apriso will get me to remission cause the next step is Remicade.
Posted 2/18/2010 1:59 PM (GMT 0)
The 5-ASA's we take are designed to be taken long term and keep inflammation down from a steady constant level of medication. Some can take it for years with no resistance and others can take it for a short time and it stops working. No one can tell you if it will stop working because it is not known why it does for some and not for others. I've been on 5-ASA's for 18 years and it's still working, however I can't take a full dose or it gives me trouble. I was on Asacol for 12-13 years when I became intolerant to mesalamines and was placed on Colazal. I reached remission with the help of 6mp but then I realized that I can't take the full dose of Colazal or I start to have issues. Another thing that has been studied is that by taking 5-ASA's it can prevent colon cancer - what the odds are, I don't know though.
Posted 2/18/2010 2:38 PM (GMT 0)
Interesting, for the past couple of weeks I've been thinking I was taking too much Colazal, because if I accidentally missed a dose I noticed the following morning I would feel slightly better, but I was too scared to drop the dose on it because of my job.
Maybe because of the lower mesalamine dose in Apriso, this could be why I'm getting better? Or maybe it is because my body no longer likes balsalaside.
Maybe 2 days is too soon to tell if it will help, but I'm really hoping it does because this is going on 7 months and I've been soo close to remission the past 2 months but never actually able to get there :/
Posted 2/18/2010 2:46 PM (GMT 0)
I reached a full clinical remission proven via colonoscopy but yet I was still having issues and my GI chalked it up to IBS. I mean, I may have IBS but I can't be sure. However, when I lowered my Colazal from 9 a day to 6 a day, those issues disappeared. While being in remission I was still having random D and a lot of cramping. So just on a whim, I decided to lower my Colazal dosing myself and things got better. I always find it ironic that one of the side effects of the 5-ASA's is diarhea (in some). Finding the right dosing and the right med is trial and error unfortunately.
Posted 2/18/2010 3:59 PM (GMT 0)
For all you know Colazal was making you worse, it did me.
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