where in the colon does a flare typically start?

After being in remission for a month I forgot to take my nightly Lialda a few times last week.  Plus I've been tapering my Rowasa doses.  Both times I forgot to take Lialda I had already taken my enema...so while laying in bed figured there was no need to get up in the middle of the night to take the missed dose if the enema was already providing a protective coating.

In any case, saw a little bit of blood yesterday and then substantially more this morning.  No urgency or cramping so I think I'm still okay - but I'm definitely going to go back to nightly Rowasa enemas and maybe 3 Lialda instead of 2.

My question: does anyone know whether a flare starts from higher in the intestine, or lower?  If it's higher, my irritation was probably caused by skipping Lialda.  If lower then maybe it's too soon to start tapering my enemas (although I was taking them nightly for about 10 weeks).

Since I was originally diagnosed with proctitus I would assume it starts lower and grows up the colon...or perhaps it's different for everyone.  Any answers/theories are much appreciated!

Thanks quincy. When I tapered the Rowasa I hadn't had any loose stool or D in about two weeks, however the latter hit me yesterday afternoon. Panic! So far no blood today but I have that slightly ill feeling in my stomach. Hoping to nip this before it gets any worse.

I used Rowasa nightly for 9 weeks which led to no blood, D, urgency, or other UC effects for the first time since March 2009. I feel like a new person and, like everyone else here, I fear going back to "that place" where I can barely leave the house for fear of losing control of my bowels.

Until this past weekend, I'd literally never missed a Lialda dosage since I started taking them in Nov. Won't make that mistake again.

Going back to nightly everything!

Hugs and best wishes to all UCers. Not fun but being able to discuss with all of you really, really helps.