If you are not a recent smoker, you will have a reaction(negative) to any nicotine. You have to get used to it and work up.
This from wikipedia:
Somebody said...
Nicotine has very powerful effects on arteries throughout the body. Nicotine is a stimulant, it raises blood pressure, and is a vasoconstrictor, making it harder for the heart to pump through the constricted arteries. It causes the body to release its stores of fat and cholesterol into the blood.[55]
It has been speculated[who?] that nicotine increases the risk of blood clots by increasing plasminogen activator inhibitor-1, though this has not been proven. Plasma fibrinogen levels are elevated in smokers and are further elevated during acute COPD exacerbation. Also Factor XIII, which stabilizes fibrin clots, is increased in smokers. But neither of these two effects has been shown to be caused by nicotine [56] as of 2009[update].
Peripheral circulation in arteries going to the extremities is also highly susceptible to the vasoconstrictor effects of nicotine and the increased risk of clots and clogging.
I quit smoking in 1994. I have recent problems with circulation in extremities and high blood pressure that I think is definitely from years of smoking. No idea if it was smoke or nicotine. I would avoid smoke though and make sure to weigh the risks of nicotine against the alternative. Once you get beyond 5ASAs and topical steriods the other drugs are pretty harsh stuff. Maybe cholestral monotoring and BP checks are a good idea?