Interesting article about MAP

From Medscape

Crohn disease

Clinical trials have failed to show any significant clinical benefit for antimycobacterial drugs used to treat Crohn disease secondary to M avium paratuberculosis.25

blueclassring said...
From Medscape

Crohn disease

Clinical trials have failed to show any significant clinical benefit for antimycobacterial drugs used to treat Crohn disease secondary to M avium paratuberculosis.25

This would be news to Dr. Borody who is one of the foremost experts on treating Crohn's with antibiotics.

See this interview for example:

www.crohns.org/treatment/borody.htm

According to Dr. Borody in regards to the response to antimycobacterial drugs:

Borody article said...
In other words, about 45% experienced complete disappearance - on our combination of drugs - of active Crohn's Disease whilst the rest have ongoing disease histologically and some clinically.

Thanks for the great links. I totally believe in some bacterial imbalance causing this whole mess. What does the CCFA have to say about it in relation to Crohn's : http://www.ccfa.org/reuters/map.

"The researchers looked into this possibility in a case-control study, involving 218 patients with Crohn's disease recruited from nine hospitals and 812 control subjects were recruited from the community. The participants completed a short questionnaire for evaluation of proxy measures of potential exposure to MAP.

Results of logistic regression analysis showed no significant association with measures of potential contamination of water sources with MAP, water intake, or water treatment."

Since when does a questionnaire about potential exposure to a bacteria allow you to infer that it cannot be the case. Good job CCFA.

Hey DanthaMan. Please, keep us updated with your progress!

How were you able to get approved for the Mycobutin? Did you get a MAP test? How long do you plan to continue taking it?

http://en.wikipedia.org/wiki/Giaconda

Giaconda used be owned by Dr Barody and used to have a web site but then a company bought it and I guess now it disappeared..

Any news about it?

has there been any further developments here? A theory that just seems to make so much sense.. but obviously has been covered up due to pharmaceutical politics

Has anyone had any success with long term use of natural anti-mycobacterial remedies such as oregano oil? or anything else?

www.rttnews.com/2202591/redhill-s-rhb-104-combination-shows-80-remission-in-pediatric-crohn-s-study.aspx

Red hill biopharma released the results of their small trial on ten pediatric CD patients not too long ago. It looks like they based it on a CDAI called "pediatric Crohn's disease activity index" and it looks like the scale of the numbers are lower than I've typically seen when just referring to plain CDAI. Either way 80 pc remission, just about any way you choose to define it is pretty impressive in my opinion. It needs a larger sample size though and I'm pretty sure to next phase is underway.

This means good news for the vaccine then?

Hopes:

1. If this proves that IBD is linked to MAP, then I’m sure that the pharma companies will finally get the kick up the butt to make something a little more effective and efficient than the antibiotic combo (they won't want to get caught out as they did when it was proved that H. pylori was the cause of stomach ulcers - it wasn't stress that was the cause, or it wasn't idiopathic as they initially thought)
2. It may mean that other natural anti-mycobacteria is also a potentially good route for me in the meantime (UC since 2 years)
3. I am of course assuming that all this route would be equally effective for ulcerative colitis (based on the ideas presented by John Hermon Taylor) and that the results will show a positive link between the effects of MAP in cattle and IBD in humans

Concerns:

1. is it likely that the MAP bug would quickly become resistant to these antibiotics?
2. Surely, even if one kills the bacteria the chances of reinfection would be high unless there is some very large scale elimination of the bug in animals too, and by the sounds of it, this bug is now rife across many different types of species and has reached most countries across the world - I wonder if pharmaceutical companies are looking into treatments to tackle this issue in cattle and other animals. It does seem that without good control of the situation further down the food chain, then the disease is likely to remain rife, no matter what developments are made in humans (i don’t believe that they have effectively created a drug to treat Johne’s disease in cattle yet – partly due to the fact that detecting it is so difficult)

For anyone interested in John Hermon Taylor's research into a vaccine and the fund raising aspect of it they are just getting their social network/internet presence updated please check out

/www.facebook.com/pages/Crohns-MAP-Vaccine/427832267319217

/www.facebook.com/RunForCrohns

Yeah, it's geared towards CD but as many have noted there is a very probable UC connection also.

If linking to sites that have fund raising is against the rules, sorry just delete this post :)

hey guys, I'm trying to find the Cinnamon (cassia) oil - thinking to include it in my diet but the ones I've found so far e.g. on Vitamin Shoppe are for external use ONLY.
Basically I want to give this and the oregano oil a shot.
Can anyone recommend me what type of Cinnamon (cassia) oil you use?

Thanks Mark - I'll give this a try.
i have an appt with GI this week and will be asking him about different approaches to my UC - to look at microbial options, other tests. I know what he's going to say :) but I'll try