Posted 7/29/2011 5:49 PM (GMT 0)
Find below a guide to selecting 5-ASA medications (including release site) that I thought could be helpful in deciding optimal treatment:
➢ Sulfasalazine – diazo bond with sulfapyradine, colonic release
➢ Olsalazine (Dipentum®) - diazo bond of two 5-ASAs, colonic release
➢ Pentasa® - ethylcellulose/5-ASA beads, small bowel and colonic release
➢ Asacol® - Eudragit-S coating that releases at pH7, ileocolonic release
➢ Colazal® - diazo bond to inert polymer, colonic release
➢ Lialda® - Eudragit-S coating of metallomatrix 5-ASA, ileocolonic release
➢ Apriso® - Eudragit-L (pH6) coating of 5-ASA-polymer coated beads, small bowel and colonic release
➢ Asacol-HD® - Eudragit-S and Eudragit-L coating, ileocolonic release
➢ Canasa® suppositories – topical rectal release
➢ Rowasa® enemas – topical rectosigmoid release