Generic Colazal

In Doors12's thread "Colazal discontinued?", AZYooper described in considerable detail all the fillers that pharmaceuticals can legally dump into generic meds! Very scary. Plus they only have to put in 80% of the main med that is used in the brandname drug!!!!!!! / Old Hat (31 yrs with left-sided UC; presently in remission taking brandname Colazal)

I don't think I did that. I posted the ingredients for one of the generic companies that was honest enough to tell you what might be inside. Personally I would trust the Roxxanne and Mylan more than the Salix pills. I have no proof but I will bet the contents of the gelatin capsule is made by the same supplier for the two SAlix pills and the two real generics. The difference is the capsule. It turned out that Watson was just the brandname sold in another bottle. A so called approved generic.


If anybody has a brandname and generics on hand, please dump the contents and compare them. I would like to know if the color, texture..looks identical. You can still use the contents. I unfortunately used all my Roxxanne and only have Mylan lying around. I am most interested in comparing brandname to roxxane or mylan.

The FDA requires 80-125% bioequivalence but wikipedia expalins that doesn't mean a 25% variation.

wikipedia said...
This value range is part of a statistical calculation, and does not mean the FDA allows generic drugs to differ from the brand name counterpart by up to 25 percent. FDA recently evaluated 2,070 human studies conducted between 1996 and 2007, which compared the absorption of brand name and generic drugs into a person’s body; they were submitted to the FDA to support approval of generics. The average difference in absorption into the body between the generic and the brand name was 3.5 percent, comparable to differences between two different batches of a brand name drug. [28][29]

I think the fact that the brandname and the generics all use the same compound means that bioequivalent dose will be very close. Not sure but I think FDA permits generics to be a different compound which is not the case here.

I would like to know more about how and by who the compound balasalzide disodium is made. If it is simple or difficult or whatever.

Color difference noticed:
I remember when I was switched from Colazal (brand) to the generic (from Roxane Labs), I noticed that the color of my urine was a lot darker.
I said to my GI...I guess the generics have more artificial dyes. He snapped back..."No, they don't".
At that time I was intimidated by him (now, not so much) and did not question him further.

I know that the color of the generic capsule is darker (more orangey) than the Colazal brand which were a light beige.

I think AZYooper meant the contents of the capsules, not the capsules themselves (they are 100% different). I notice the darker urine even with the brand name Colazal...too soon to tell with the Mylan.

Is the yellow powder the natural form of this med?

I can't see why they would color the contents but no idea that is why I wanted somebody to dump samples out and look at them.

I just emptied a mylan capsule and it is a brownish yellow powder sort of the color of ground cumin. When you put it in water it colored an entire glass a brownish yellow. Very strong dying property. I can't believe they would add that much dye so it must be the chemicals natural color. Being a cheapskate I drank it. It tastes pretty bad. If I stop posting I died. The gelatin melts just getting damp so that explains my heartburn when taking the pills on empty stomach.

jp19..welcome to the forum.

The enemas would definitely cover 15 cms (6 inches) without the fancy acrobatics. You'd just have to lay on your left side.

You might want to consider another oral topical 5ASA such as Asacol.

What exactly are your symptoms at this point?

q