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Transdermal dose question for InSoFla (or anyone)

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Ulcerative Colitis
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Posted 5/1/2012 10:47 AM (GMT 0)
Good to see InSoFla back. Anyone who has tried transdermal LDN though- how does one get an rx for it in terms of dose? I have been taking oral 4.5 mg LdN for around a year- had a good ten month med free remission but lately am flaring on and off again and am (knock on wood temporarily) at least low dose pred dependent again and anxious to regain med free remission. Though frankly I see no reason why transdermal should have any more effect than oral, as absoprtion occurs in the small gut which is free of inflammation in my case, I am still keen to try anythng at this point. Does Skips pharmacy know the equivalent and how should the rx be written out, in terms of dose per day? Thanks.
Posted 5/1/2012 11:37 AM (GMT 0)
Are you also using diet mod. along with LDN? I believe InSoFla believes there should be a multi-faceted regimen, not just LDN alone to achieve positive results.
Posted 5/1/2012 11:46 AM (GMT 0)
Before going to the cream you should stop taking your ldn for a week or two and then start it again. I read that if it becomes ineffective after a long period of use you can do this to restart it. I'd try that first.
Posted 5/1/2012 12:00 PM (GMT 0)
@Imagardener2- yes, I have been doing dietary modification for years- low carb SCD/paleo (though I was an SCD yogurt lover, I do best dairy free except for occasional butter with my veggies), plus a host of powerful probiotics and supplements (eg turmeric, fish oil, currently added CLA); @Gonk- yes, thanks- am a few days into having stopped LDN and will see if I can kickstart it again. Anyone have any hard data, scientific paper links on becoming desensitized to LDN and having to do that protocol? my alternative MD agreed it is worth trying but he is not experienced in LdN- fortunately he helps me with all my requests.

Other things I am going to try are resveraratrol and Lecithin enemas. Thinking aout trying slippery elm but am afraid it will be like boswellia or aloe, which flare me.
Posted 5/1/2012 12:35 PM (GMT 0)
Probiotic,

I would suggest you call Skip's Pharmacy and ask them how does the script have to be written exactly for the transdermal LDN?

I think Gonk's idea of stopping the LDN for a bit is a good one, however I believe week is too much, IMO 5 days would be a better hiatus. I've read a few anecdotal stories about people doing that to re-start the LDN effects with great success. What I've been doing is every couple of weeks, I'll skip 2 nightly doses in a row, and then re-start again. 

With regard to trying slippery elm powder, IMO it's worth a shot.

I tried boswellia and had no success with it. Be careful with Lecithin, I've read that it can goes great gastro-intestinal distress.

I know that ItsAlwaysSomething tried the homemade version of slippery elm powder enemas, which helped her alot.


 

Posted 5/1/2012 1:12 PM (GMT 0)
Thanks and welcome back, InSoFla- makes sense to pulse off the LDN like that, if this desensitization issue is true. I will call skips- I should definitely order some transdermal- no harm in at least comparing it. When you say you didnt respond to Boswellia- did you happen to get any increased pain from it, like I did? (I am done with ever trying it again but just want to compare reactions, you do well on slippery elm, which seems to have made some ithers on this forum worse - the usual YMMV situation of course.)
Posted 5/1/2012 1:21 PM (GMT 0)
Thanks Probiotic.

As to the Boswellia, I took it for a few days ( in pure powder form, for more effect) and found it did nothing, I don't remember any increased pain from it.

Let me know what happens with Skip's and the transdermal.

Posted 5/1/2012 3:01 PM (GMT 0)
let me suggest, if you have low blood pressure, cortisol, thyroid, DHEA or adrenal fatigue LDN might make it worse, it did for me. I need to get these in check to get back on LDN. LDN just made me more tired then ever! I was sleeping 12 hours then taking a three hour nap during the day, barely worked out and if I did it was a half hour because I had no energy.

The information from the yahoo group LDN, filled me in on this. So if you have no issues with these things go ahead with LDN.

I hope it works for you!

Posted 5/1/2012 6:32 PM (GMT 0)
MY LDN PREscriptION WILL BE 55$ , ALTHOUGH I WAS QUOTED FROM ND IT WOULD PROBALLY BE 35-40$. IS ANYONE ELSE PAYING THIS ?
Posted 5/1/2012 6:39 PM (GMT 0)
yeah somewhere around $46
Posted 5/1/2012 9:01 PM (GMT 0)
For what amount, how many pills?

Typically, a 3 months supply of sucrose filler pills (they are slightly more expensive than the rest) is around $59.

The transdermal cream is around $59. for a two month supply.

Posted 5/1/2012 9:38 PM (GMT 0)
Hmm, LDN has never affected my blood pressure, sleep, alertness or anything like that in any way... I guess like anything some are sensitive. I will definitely call Skips regarding proper dosage. I'm also curious about the 4.5 mg standard oral dose and if it should be adjusted in terms of mg/kg if one is larger or smaller than than average- i.e. Is the therapeutic efficacy that sensitive to being overdosed such that it is no longer "low dose", or does it not matter that much.
Posted 5/1/2012 11:42 PM (GMT 0)
Isn't dosage based on body mass? In a case of a 110 pound woman would have a 3.3 mg dosage. Weight in pounds x .03

That's what I've read.
Posted 5/2/2012 12:40 AM (GMT 0)
Prescription should be written like this.

Naltrexone Cream 4.5 mg/1 mL 

Apply 1 mL every night at bedtime. 

My doc dispensed a 90 day supply so I got 90 mL in 30 syringes. 

 

Posted 5/2/2012 11:55 AM (GMT 0)
Thanks, Sibby and blueclassring- very useful.
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