Madpotter,
You need to have the proteins in your urine checked asap! Lialda can cause proteinuria (aka, nils/minimal change disease) whereby your kidneys do not filter properly and you lose proteins and your ankles swell. I saw many GP's and specialists it took me 7 years and my current GI to have me pee in a cup to tell me that I was having this type of problem. You should fire your GP for ignoring this!!!
Yes the swelling gets worse during the day for people with proteinura too. It could totally be something else but definintely get that checked. Mine swells in one ankle more than the other b/c I sit on on leg during the day.
There have been a few other people on here who have had that too, it is called Minimal Change Disease and mostly it reverses when the medication is stopped and a course of prednisone but since I was undiagnosed for so long my theory is that my kidneys are scarred and they wont fully heal but wont get worse either.
Please, please get this checked! Let me know how it goes. Any questions please just ask.
Beth