Continuous Opioid Receptor Blockade and UC

I am starting to wonder if we are not suffering from a continuouis opioid receptor blockade from exogenous

substances in our diet, such as coffee,wheat,dairy/milk,red meat.

If the endorpins are blocked every time we eat certain foods and we are genetically predisposed,what happens????

We all know that some peoples UC is helped if they stop eating these items,and that the SCD works on some,and

others on the SCD have eliminated dairy and it works better.

We also know that LDN works on some people.

We also know that Paleo works on some people, wheat,dairy,and many other carbs are eliminated. Could even be a reason vegetarians get UC.

I am just starting to look into this,and it is not that easy to find info,on what happens to the

immune system with a continuous blockade.

This one says that high dose naltrexone depletes the immune system,have to check it out more.

http://community.wegohealth.com/profiles/blogs/multiple-sclerosis-and-low-2

http://bloodjournal.hematologylibrary.org/content/95/6/2031.full

You can see from this article that dairy and wheat when broken down in the gut produce opioid receptor blockers.

http://www.childrensdisabilities.info/allergies/developmentaldisordersprotein7.html

http://xa.yimg.com/kq/groups/18630837/685088275/name/Exorphins.pdf

The chlorogenic acid from coffee also is a receptor blocker.

http://www.nature.com/nature/journal/v301/n5897/abs/301246a0.html

http://vanderbilt.edu/ics/Files/QUINIDE_opioids.pdf

Here are some other foods with high chlorogenic acid content,notice the nightshades.

http://mpkb.org/home/food/chlorogenic_acid

Hi dose LDN

http://www.elaine-moore.com/Articles/LowDoseNaltrexone/BenefitsofLowDoseNaltrexone/tabid/112/Default.aspx

Not quite sure what this one is saying.  Looks like they might want to revisit milk and IBD.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856222/pdf/756.pdf

http://www.jci.org/articles/view/16750

Hi dose naltrexone side effects.

http://www.drugs.com/sfx/naltrexone-side-effects.html

More studies.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856226/pdf/815.pdf

Bottom line ,if the opioid receptors are blocked by agonist or antagonists,

from eating dairy,wheat,coffee,tea,red meat,nightshades by consumption of food during the

day,then the endorpins cannot attach to the receptors,and immune dysregulation occurs.

There is also of course a genetic component.

It would appear that LDN can displace these agonists/antagonists,at night when you are not

eating,and cause the rebound effect,where incresed endorphins are produced and more

receptors are also produced.

It would be real interesting if this turned out to be correct.

I know many are on a no dairy,no wheat diet,but wonder how many are also on a no nightshade,no coffee,

no tea,no blueberry/apples,in addition to no wheat and dairy and red meat diet. and still have UC.

Running out of things to eat.

Old Mike

 

Post Edited (Old Mike) : 5/23/2012 6:19:17 PM (GMT-6)

LDN is an opioid receptor antagonist. It blocks the binding of agonists, including endogenous opioids like endorphins. It is thought that, by blocking opioid receptors, the body will increase its production of the endogenous agonists which may have a positive effect on immune function in people with autoimmune diseases.

Very interesting, still makes you wonder why all of a sudden UC symptoms can hit, or go into or out of remission with seemingly no rhyme or reason. Perhaps we are unaware of slight changes we make that become our triggers.

kloe0038:
I wish I was a biochemist,anyway perhaps for the same reason that high dose Naltrexone does not work like LND. Something different happens when the receptors are blocked/binded with exogenous compounds on a continuous basis.
I have asked the same question of myself ,need to look into it more.
I have read so many studies today,I may have ran across it but have forgotten.

I knew I read this today here is something by the doc who invented the use of LDN.

http://www.lowdosenaltrexone.org/gazorpa/interview.html

This page gives a little more.

Looks like too much Naltrexone just blocks the receptors from

endorphins,but probably more complex than that. Page down.

http://www.lowdosenaltrexone.org/ldn_and_ai.htm

So getting back to all the exogenous receptor blocker agonist/antagonist we eat. Might these work just

like high does Naltrexone and block endorphins from attaching

to the receptors.

I did not know until this morning that the above foods, when digested broke down into receptor agonists/antagonists.

Not a

huge amount of info on the subject of certain digested food turning into receptor blockers.

Old Mike

Post Edited (Old Mike) : 5/23/2012 7:06:56 PM (GMT-6)

Kloe0038:

One other point is that,

with high does Naltrexone the people feel terrible,this is due to blocking of their own endorphins. This is from the doc who discovered the use of LDN. If the receptors were up regulated then how could the high dose Naltrexone continue to block the receptors.

Of course I can be completely wrong. Many of these peptides are agonists,but I do not believe the papers indicate what kind of agonists, if they are inverse agonists,then something else may be going on.

Chlorogenic acid,looks like it is a potent as naloxone.
http://www.ncbi.nlm.nih.gov/pubmed/15088081

http://www.nature.com/nature/journal/v301/n5897/abs/301246a0.html

http://www.ncbi.nlm.nih.gov/pubmed/6259732?dopt=Abstract&holding=npg

http://www.ncbi.nlm.nih.gov/pubmed/372181?dopt=Abstract&holding=npg

http://en.wikipedia.org/wiki/Gluten_exorphin

http://fondation-maladies-degeneratives.org/Articles/a0f14213437ad7df55b7176fcea35bdf.pdf

This is interesing,not sure I understand it all but these peptides seem

to be active.

https://ncur.weber.edu/ncur/archive/Display_NCUR.aspx?id=21493

I think I new about exorphins but was not paying attention to them.

As far as upregulation of opioid receptors with chronic Naltrexone.

If the receptors are upregulated,but we keep ingesting large amounts

of foods that break down into bio active peptides, is not it possible

that an equilibrium is set up where these exogenous peptides still have an suppressive effect on the action of endogenous endorphins,

and or binding.

Old Mike

Post Edited (Old Mike) : 5/24/2012 3:54:38 AM (GMT-6)

Mackster:
I am just a laymen trying to connect the dots.
The doc's are not real interested in anectodal reports.
They are pretty much only interested in evidence based medicine.


Old Mike

Old Mike...sometimes you hurt my brain! :) You usually post some interesting things (and that's a good thing!) but some of these things are so darn technical and hard to understand. The topics you bring up are so complex - it's like the whole time/space warp continuuim (sp?).

Wow Oldmike; this is some really good research!!! Like someone else mentioned i wish the docs were looking at this forum and trying to put the dots together.

I really don't know what to say except that i don't know who can try this kind of diet. It would be highly restrictive. Because no wheat and then no potato (nightshade) so you just have to eat rice for carbs. And no milk too? that's really hard.

I dunno my head is spinning right now. I have tried too many things at this stage and still if i try to taper the rectals i bleed. Im using two suppositories per day (should only use 1) to keep things at bay -barely!! And i wonder how long this is gonna continue working for.

Your posts make me scared to eat anything, use soap, wash my dishes, take showers, drink water, and basically do anything related to staying alive. lol

Hope it works for you. :)

Danthaman: I took both low and high dose chlorgenic acid for about a week at different times,did not seem to have an effect on me. But that is me.
Right now I am messing with vitamin K2 mk-7.
Old Mike

Good find.

Perhaps there is something in the food causing a blockade of receptors.

Old Mike

I will have to start from scratch,perhaps.
Seems that spinach also contains endorphins,I have another thread somewhere on orange juice blocking LPS,the thing about lps from foods is it cant be destroyed,but might be washed off.
Whatever happened with your grapefruit naringin test.
Old Mike

Makes you wonder if we have lots of endotoxin in the blood then perhaps endorphins are depleted.

http://www.nature.com/nature/journal/v275/n5679/abs/275450a0.html

Something going on with blood flow,and mesentaric blood flow.

http://www.ncbi.nlm.nih.gov/pubmed/1541102

There is an endotoxin endorphin connection.

http://iai.asm.org/content/48/3/813

http://iai.asm.org/content/48/3/813.full.pdf

Post Edited (Old Mike) : 11/25/2012 7:05:46 PM (GMT-7)