Bugs-R-us : 3 good articles on human microbiome and immune function

I think the 2nd one is best because it looks at how the good bacteria and the immune system actually communicate. I think this is one area where progress will come from.

I recently posted some info from a 2012 probiotics review article that I like a lot:


A little difficult, but very helpful probiotics article that also reviewed the key parts of the immune system, the current medications, research, and ways probiotics can help.



It is titled:

Microbes, intestinal inflammation and probiotics. Expert Rev. Gastroenterol. Hepatol. 6(1), 81–94 (2012)



I don't have a public link, and do not want to post copywrite material, but possibly I could send a copy by email if somebody really wants to struggle through the article. There were some useful drawings of the immune system and the mucosal lining.



The key points were:



The molecular and cellular mechanisms of the etiology of irritable bowel disease are not yet completely unraveled

Microbiota in the intestine governs the intestinal<span style="mso-spacerun: yes"> epithelial-immune interaction.

Disturbed bacteria host relationships in the intestine are looked upon as potential etiologic factors that trigger inflammation.

A better understanding of bacteria-host in vitro and in vivo Interaction is necessary.

In addition genetic susceptibility predisposes the host to disturbed intestinal epithelial-immune Interdiction and recurrent disturbed epithelial barrier functions and intestinal inflammation.

Probiotic as a therapeutic approach for IBD has shown some promise in recent years. and VSL#3 is the Iconic example.

Probiotic5 help in restituting the disturbed microbiota population and the intestinal epithelial-immune homeostasis in the intestine, without significant side effects.

Recent advances in genetic interventions with the bacterial lipotechoic acid have opened new avenues to study the host bacterial relationship.

Genetically modified lipotechoic acid deficient Lactobacillus acidophilus has shown significant benefit In the colitis mouse model in comparison with wild-type L. Acidophilus.

The next 5 years will see numerous studies with various genetic Interventions with intestinal commensals to study the role of specific bacterial components, such as various surface layer proteins in host-bacterial interaction.

Well, I am seeing a lot of colitis-inducing i e toxic references to b. fragilis thus far... It may be like e. coli, whereby we need a specific non toxic variant (as mutaflor provides with nissle 1917)... Will search some more.