Prednisone dosing question

If you're prescribed, say, 40 mg/day, do you take the entire 40mg at once or do you split it up in the day? I've been on 40 mg for the last 2.5 weeks, taking 20mg in the morning and 20mg in the evening, and my symptoms have fluctuated greatly (currently NOT GOOD). Then this morning I took all 40mg at once (desperate for relief) and my symptoms have improved greatly over the last 5 hours. Maybe its nothing, but I wanted to check and see how you all take your dosage.

I also started off spliting the dose 20mg/20mg but it did not clear up my symptoms. My GI recommended taking at 40mg before 8am with food and this should help. You may find that it wears off in the middle of the night so taking a meslamine enema may help. I also took Cortifoam in the AM. When I was first diagnosed in 2005 I took 60mg all at once and my symptoms improved immediately. During my last flare I took 40mg for 8 weeks before I got down to 1 -2 BMs a day. I could never taper successfully so after 7 months of Pred I was ready for Remicade. I have had 3 infusions and I am finally off the dreaded pred!

Thanks for the replies. I am really shocked at the change in my symptoms over the first half of the day. I can only assume its because I took the entire does in the AM but can't be sure. Hopefully this does the trick...my GI wants to try Remicade or admit me on Monday for IV steroids if my symptoms don't improve.