Beta Oxidation Inhibitors-Diet Some UC Dots Might Have Just Connected.

Not good, ammonia in the colon inhibits beta oxidation.

This again is pointing to our friend excess protein in the diet,still need

to look and look and look at this.

http://ajpgi.physiology.org/content/285/1/G105.full

It also appears that the type of fiber will determine how much ammonia is generated on protein diets. This gets more and more complex. 

I am starting to go nuts.

It might also imply why strict Paleo works,if you are on a very low fiber diet the ammonia is less,but pectin

makes it much higher, cellulose lowers it. Might also explain why vegetarians get UC,too much pectin even on no meat diet.

http://jn.nutrition.org/content/119/2/235.short

Low pectin fruits.

http://foodpreservation.about.com/od/Preserves/a/High-And-Low-Pectin-Fruit.htm

Revised pectin amounts.

http://naldc.nal.usda.gov/download/22783/PDF

Really need the nutrition people here to possibly suggest a low pectin high cellulose diet.

I can only guess.

Some dots are starting to connect.  I am getting exited,and that is hard to do.

Some low pectin veggies.

http://www.livestrong.com/article/497197-list-of-foods-low-in-pectin-and-white-flour/

Seems that ripe and over ripe fruits have less pectin.

Dont know if there is a follow up or not,but they should have done a high pectin high cellulose diet. This would

show if high cellulose lowered the ammonia in the presence of pectin.  Also rats are different than humans so need to look for some kind of human studies.

Here is one they cross over from aussie to china type diet in humans

got more fecal ammonia on china diet.

http://www.ajcn.org/content/68/2/372.full.pdf

 Colon Cancer in black africans,less than whites, low meat.

http://www.ncbi.nlm.nih.gov/pubmed/10235221?dopt=Abstract

Almost everything you might want to know about scfa but still not the

what I am looking for.

http://physrev.physiology.org/content/81/3/1031.full#ref-289

Interesting regular veggies dont work but soy does.

http://www.ncbi.nlm.nih.gov/pubmed/12235653

Prebiotics dont work,dog guts are a better test than rats.

http://www.ncbi.nlm.nih.gov/pubmed/14641959

Another big study,says ammonia not much different,looks like some difference.

http://www.ajcn.org/content/early/2011/03/09/ajcn.110.002188.full.pdf

 Rye wheat study.

http://www.ajcn.org/content/77/4/967.full?referer=www.clickfind.com.au

Meat fermentation colon.

http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201100542/full

Old Mike

 

Post Edited (Old Mike) : 8/22/2012 6:59:41 PM (GMT-6)

This is not as easy as it might look,been working on it all day.

Veggies like broccoli dont work.

Green banana,soy,rye,wheat bran,might help,not sure on greens yet in humans,might never find out.

From one study the only way to do it is lower meat consumption,veggies dont do much.

Whole point is to try and lower ammonia so it wont interfere with butyrate oxidation. It is possible that lower stool ph is good where ammonia is inactive.

http://jn.nutrition.org/content/141/5/883.long#T1

Wheat bran and Rs.

http://www.ncbi.nlm.nih.gov/pubmed/15159232

Rye still looks good,but not for ammonia.

http://www.ncbi.nlm.nih.gov/pubmed/10958815

Lots on butyrate.

http://onlinelibrary.wiley.com/doi/10.1002/ibd.21108/full

They have not looked at ammonia yet in humans according to the above,are you kidding me.

I got another one which is all over the place,sulfite ions.

http://www.springerlink.com/content/4943639g2v0m1337/

Mercaptoacetate is a potent beta oxidation inhibitor,

can be made in the colon from sulfated polysacchrides

carraggeenan.

http://gut.bmj.com/content/46/2/218.full.pdf

Old Mike

Post Edited (Old Mike) : 8/23/2012 8:52:52 AM (GMT-6)

I have now found a reference to mercaptoacetate formation from
carageenan,see my last reference. Mercapto compounds are also
strong inhibitors of beta oxidation.
Remember colitis usually starts distally. SCFA such as butyrate deplete distally and protein fermentation and ammonia concentration
and hydrogen sulfide increase distally. Even if there is enough butyrate if the reactions are inhibited the colon cells cant use it.

Carnitine might be one way around some of the problem.

http://www.ncbi.nlm.nih.gov/pubmed/17065219

Seem to be something to it.

http://www.ncbi.nlm.nih.gov/pubmed/21929562

http://www.pulsus.com/cddw2011/abs/088.htm

These docs are not sure.

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2011.04913.x/full

It would also seem that you want to decrease transit

time.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891451/pdf/v041p00245.pdf

This is a good rundown on colon nutrition.

http://www.angelfire.com/folk/cusp/images/large_intestine.pdf

More on protein fermentation and mercapto acids in the colon.

http://www.open-access-biology.com/probiotics/hughes/hughes.html

Take off the meat.

http://gut.bmj.com/content/53/10/1399.full

Old Mike

Post Edited (Old Mike) : 8/23/2012 6:26:13 PM (GMT-6)

Dantha: It has been so long since I read this stuff,what are ALC and PLC.
OM

Old Mike said...
Carnitine might be one way around some of the problem.

I can test this starting *now* half the weightlifting products contain it and I think I have a few bottles of just l-carnitine.

L-carnosine does not count but many of these powders do have L-carnitine.

One bottle of Carnitall 600+ has several variations of LC and ALC. 2 pills down the hatch, need newer bottle.

Will this suffice for experimentation with some of the other ingredients ?

www.amazon.com/Jarrow-Formulas-Carnitall-600-Capsules/dp/B0013OX8FG/ref=sr_1_1?ie=UTF8&qid=1363655102&sr=8-1&keywords=carnitall+600

Carnitine exists in two stereoisomers: Its biologically active form is L-carnitine, whereas its enantiomer, D-carnitine, is biologically inactive.

Post Edited (aguywithuc) : 3/18/2013 7:19:59 PM (GMT-6)

This item contains arginine,for me that is not good,makes me worse.

It has the alc and plc,but there is so much other stuff that if it does work,you might not know why.

In the long run might be better to try just alc and plc.

OM

http://www.vitacost.com/jarrow-formulas-carnitall-600-plus