pH/Sunlight and immune function Neutrophils suppression and migration

Might as well try and get it all in one thread.  Seems that neutrophils are a major

part of our problem. Simply removing them from the blood, or perhaps blood letting can put people into remission.

My neutrophils in routine blood test over the past 10 years are high out of range.

Not sure where this might go,but perhaps it might explain the alkaline diet and

why it helps some with UC. Also more on sunlight.

Old Mike

http://www.jleukbio.org/content/69/4/522.full

http://ajcn.nutrition.org/content/76/6/1308.full.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC498851/pdf/jclinpath00177-0104.pdf

Sunlight seems to suppress,never saw this before/might explain some things with UC.

http://www.jleukbio.org/content/65/5/573.full.pdf

Removing neutrophils.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274988/

Migration,garlic pills are a blood thinner,the only effect I saw from them is I bleed more.

http://www.ncbi.nlm.nih.gov/pubmed/11330220

http://www.ncbi.nlm.nih.gov/pubmed/20589735

resveratol,tried it in the past, no effect on me.

http://www.impactaging.com/papers/v2/n4/full/100143.html

http://www.nutraingredients.com/Research/Chronic-colitis-patients-could-benefit-from-resveratrol-says-Spanish-study

RESVERATOL FAKED DATA not sure if the fakes concerned UC or not.

http://www.cbsnews.com/8301-504763_162-57357720-10391704/red-wine-researcher-dr-dipak-k-das-published-fake-data-uconn/

LTB4 attracts neutrophils.The way to lower is low veggie oils and take fish oil.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383307/

GM CSF perhaps a key,cant get this link to work,dont even know what it was.

http://download.springer.com/static/pdf/850/art%253A10.1007%252Fs00384-008-0509-x.pdf?auth66=1354903950_6f0d0ba14ebc0908b0c63d804173878b&ext=.pdf

Antihistamines work on others but not gmcsf

http://www.ncbi.nlm.nih.gov/pubmed/10772385

Vitamin C as a regulator,have taken up to 4 grams a day with no effects.

http://bloodjournal.hematologylibrary.org/content/99/9/3205.full.pdf

Vitamin D also involved.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC104378/

HYC can up regulate magnesium can down regulate. My Hyc is high.

 http://dermatology.cdlib.org/147/review/neutrophils/aronson.html

B3 upregulates.

http://www.signaling-gateway.org/update/updates/200903/nri2521.html

Fish oil.

http://www.jleukbio.org/content/71/6/981.full.pdf

Steroid resistance,interesting,vitamin d connection.

http://130.88.242.202/medicine/Aspergillus/Dropbox/Aspergillus_Website/aspergillus-web/articlesoverflow/19482216.pdf

Bromelain is possible.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2269703/

Whey seems to stimulate,not sure if good or bad.

http://jn.nutrition.org/content/139/2/386.full.pdf+html

interesting

 http://www.biomedcentral.com/content/pdf/1476-511X-10-235.pdf

does b12 make us worse,seems to be necessary to make neutraphils.

http://www.livestrong.com/article/541164-low-neutrophils-and-a-strict-vegetarian-diet/

http://pptu.lefora.com/2012/06/20/neutrophils-protozoa-and-nutrition/

Fermented whey,might be a key. click on look inside the book,you really need to read this.

http://link.springer.com/article/10.1007%2Fs00011-009-7100-y?LI=true#

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1845142/

http://www.ncbi.nlm.nih.gov/pubmed/10532380

 Opioid receptor protein fragments.

http://www.ncbi.nlm.nih.gov/pubmed/11242443

http://www.ncbi.nlm.nih.gov/pubmed/12769741

Magnesium

http://www.ncbi.nlm.nih.gov/pubmed/11895162

Mag CRC and inflamattion.

http://www.ncbi.nlm.nih.gov/pubmed/23125223

 

Post Edited (Old Mike) : 12/11/2012 6:32:04 PM (GMT-7)

Sure a balanced diet of real food,will help to insure you have all the amino acids necessary for
a healthy body. Synthesis of some may be blocked for some reason,don't know.
Old Mike

Agreed, we need balanced diet, at the same time, we need to factor in the quality of current produce. I doubt its as nutrutious as our parents'.

Vit D, Isn't there an old link? Actually, came across a study a while ago that the folks living in Hawaii, white skin, regular surfers, were low on Vit D !! In this case, we certainly need to question Vit D levels of folks living up north.

Believe it or not, I try to eat alkalinising food. I don't care what others think but I follow.

I have tried digestive enzymes in the past,no luck,I did this when much younger,found out I could drink
more alcohol, without feeling it,go figure.
Old Mike

My point was even though you may have tried that you may still no be getting the essentials. Read below or go to the link for more on it. I think it is very relevent.

"Eating sufficient protein is not in itself a guarantee that the necessary amino acids will be supplied. Even though amino acids are the substances of which proteins are made, no matter how much protein we consume, the biological availability cannot be assured. This is extremely important to understand. Namely, that protein, be it sourced from food or cellular body protein, must be completely broken down into its constituent parts before it is of any use and value.

Whatever the reasons for the inadequate digestion of protein, it is obvious that there can be an actual deficiency in certain amino acids due to one of the following factors:

• incomplete breakdown of proteins in the digestive system.
• inherited abnormalities in the biochemical mechanisms of the body
• a poor diet.

Let us explore some of the major factors behind poor amino acid absorption or protein synthesis:

• Digestive Factors
• Allergic factor
• Diet Choices
• Biochemical individuality
• Insufficient Support Nutrients
• Aging
• Disease Weakened Metabolic Systems"


Link:
http://www.aminomics.com/aminoacids/why-deficient.htm

Steve

You really need to read some of this stuff,click on the read inside button.

This is on fermented whey,inhibits neutraphil infiltration,they use bacteria from keifer.

Old Mike

http://link.springer.com/article/10.1007%2Fs00011-009-7100-y?LI=true#

http://www.ncbi.nlm.nih.gov/pubmed/10532380

Opioid receptor protein fragments,from fermented whey and even spinach.

http://www.ncbi.nlm.nih.gov/pubmed/12769741

Post Edited (Old Mike) : 12/7/2012 8:29:38 PM (GMT-7)

twiggs said...
OM,
General Amino Acid Deficiency Symptoms

In general, if you're deficient in any particular amino acid, your body won't be able to synthesize the full range of chemicals it needs for proper function.

Also,

Specific Amino Acid Deficiency Symptoms

I took what was relevant to our issues but my link provided more on the list other than these specific to us.

•Weak Immune System -- The immune system is also one of the first systems to suffer as a result of an amino acid deficiency. Not only this, but an improper ratio of amino acids in the body can also cause a weakened immune system. This is the reason why protein is said to boost the immune system, because protein is comprised primarily of amino acids, which help to bring the immune system back to normal function.
•Inefficient Digestive System -- Without the proper amino acids, the body has a difficult time producing enough digestive enzymes and other compounds that help the body to properly digest and absorb food. This doesn't occur with just digestive enzymes either. There are two types of enzymes used by the body, digestive and metabolic. And there are multiple thousands of different enzymes. So a deficiency in one or more amino acids can cause a deficiency in the body's enzyme supply

Steve

I can save you some time. If your a vegetarian then perhaps this is true for you. It is certainly not true for anyone who body builds because we are always consuming protein powders that always contain all 8 essential amino acids. I have 2 favorite products and checked to be sure but of course they include all 8. I also eat eggs every day and ..

"Eggs contain all nine amino acids, plus all three essential fatty acids. Other complete sources come from animal products. Plants are usually deficient in at least one. "

I have consistently consumed all 8 since before my UC began in 2006 yet I still have UC.

Aguywithuc, Did you read this yet? It explains why even though you may eat it you may not be absorbing it..So it may be that now that we have UC it may further complicate this as we may not be able to absorb it as a result. I remember posting a link discussing a test for this to see if we are getting it properly then we dont have to assume we are based on food consumption/ digestive factors.

"Eating sufficient protein is not in itself a guarantee that the necessary amino acids will be supplied. Even though amino acids are the substances of which proteins are made, no matter how much protein we consume, the biological availability cannot be assured. This is extremely important to understand. Namely, that protein, be it sourced from food or cellular body protein, must be completely broken down into its constituent parts before it is of any use and value.

Whatever the reasons for the inadequate digestion of protein, it is obvious that there can be an actual deficiency in certain amino acids due to one of the following factors:

• incomplete breakdown of proteins in the digestive system.
• inherited abnormalities in the biochemical mechanisms of the body
• a poor diet.

Let us explore some of the major factors behind poor amino acid absorption or protein synthesis:

• Digestive Factors
• Allergic factor
• Diet Choices
• Biochemical individuality
• Insufficient Support Nutrients
• Aging
• Disease Weakened Metabolic Systems"


Link:
http://www.aminomics.com/aminoacids/why-deficient.htm

Steve

Post Edited (twiggs) : 12/9/2012 10:39:15 AM (GMT-7)

twiggs said...
Aguywithuc, Did you read this yet?

Steve

Thanks for summarizing. Every quality protein powder out there are essentially pre-digested and comes with enzymes to further break it down. Lets assume adequate quantities are not being absorbed, what are your proposing as the remedy ?

Ok they are offering their highly bio-available proteins and enzymes as the 'remedy'.

"the ISM medical team is able to design an ISM© Balancing Compound to address the cause."

Like I said I buy the best bio-available protein out there and it comes with enzymes and I take Pancreatin and Digestall. I do this in order to gain muscle/weight and it has never ever improved my UC.

If you take the plunge and report that their 'blueprint' for you is effective I will also try it - for now I think its the same old song and dance wrapped in pseudo science but I remain open minded.

Thanks for drawing my attention to it. I would like to hear testimonial from people on this board before I try because I bet they have a really high price tag.

It appears to be a ripoff:

"In 2001, CCRG's services cost CN$150/hour for assessment and evaluation (typically $750), $1,500 for "development of therapeutic plan, $10,000 ($5,000 in advance and $500/month for 10 months) for "orthomolecular diagnostic and assays," and $4,000 per "treatment cycle" for "immunotherapy" (maximum 4 cycles per year). Purchasers are asked to sign a "consent" form agreeing "to not hold liable Canadian Cancer Research Group for act or activity as it relates to the treatment of my cancer." "

"In 2005, O'Neill announced that Immune System Management (ISM) had "purchased the intellectual assets of CCRG" and intended to open a chain of clinics throughout Canada. However, it appears that the Ottawa clinic (now called ISM Clinic and Lab) is the only facility. O'Neill is ISM's board chairman. CCRG's Web site, which has not been updated since 2005, says that its programs are based on a blood test he calls the "Aminomics Profile." It states: "Your Aminomics Profile will be developed and compared to the Optimal Profile and you and your Case Manager will review a detailed report of our findings."

www.quackwatch.org/01QuackeryRelatedTopics/Cancer/ccrg.html

Post Edited (aguywithuc) : 12/9/2012 11:45:56 AM (GMT-7)

twiggs said...
Well these are the possible reasons so they say. I am not sure why yet and still researching the detail of these listed but its a start in understanding if it is the case anyways. Predigested is a good way to perhaps "see to it" if you will that they get in your system. But even then are we sure? I guess the amino acid test would be the only way to be sure. I mentioned that before but dont have the link handy for the test. It can be easily searched on if you wish to have it done.

Let us explore some of the major factors behind poor amino acid absorption or protein synthesis:

• Digestive Factors
• Allergic factor
• Diet Choices
• Biochemical individuality
• Insufficient Support Nutrients
• Aging
• Disease Weakened Metabolic Systems"

Steve

That is from their website and as I pointed out above it is a scam so I discount any info from that website.

I would say that if I am not absorbing protein it is because of UC inflammation and not the other way around. All they are offering is more enzymes etc and since I am already doing that - not much traction in this direction.

twiggs said...
I didnt notice they were selling something but was just searching on criteria to see what I could come up with. I guess I could look more into if this quote they made is really valid or not. And if valid other reasons why even with properly broken down protien one would still not get it properly.. I am just digging here.

"Eating sufficient protein is not in itself a guarantee that the necessary amino acids will be supplied. Even though amino acids are the substances of which proteins are made, no matter how much protein we consume, the biological availability cannot be assured. This is extremely important to understand. Namely, that protein, be it sourced from food or cellular body protein, must be completely broken down into its constituent parts before it is of any use and value."

Steve

"must be completely broken down into its constituent parts before"

Thats what the enzymes do, my powders come with enzymes in them and adding more also makes no change.

They sell enzymes etc.

Old Mike said...
What I believe they are doing with the protein matrix is basically making yogurt from the whey.I tried a batch the other day,did not work,mixed milk with whey added some yogurt and incubated,nothing much happened,believe the yogurt bacteria may have been dead.

If you are going to take magensium supplements, watch it.
I took 2 pills over the RDA for magensium and urine ph shot up over eight,colon did not like the
high ph either.
Was using a mixed pill of mag oxide and gluconate.
Mg chloride might be the best stuff but a little difficult to find,and it is hygroscopic.
Otherwise not sure yet which is the best salt.
The maximum tolerable dose of mag is 350mg a day,watch how much you take,especialy if eating
high mag foods.
Old Mike
http://en.wikipedia.org/wiki/Magnesium_citrate

Oral route is always bad for me. I used spray on magnesium to relax when having insomnia or muscle tension.