question for predfoam users

I have been using predfoam twice a day for two weeks now after suffering from severe lower abdominal discomfort thought to have been caused by the mesalasine suppositories.
The discomfort has somewhat subsided although I do still feel tender very lower down.
However over the last week I have been suffering severe cramps on waking. I always need the loo as soon as i wake but have never had theses cramps before. I maybe have at least 4 bms with abdominal cramping for at least an hour or so after waking.

Wondered if the predfoam was causing this. Has anyone elsegot any experience of this. I don't usually need to go to loo then for the rest of the day.
I currently take 3600mg of mezevant plus probiotics, vit supplement, turmeric and zinc. I also take trazodone for depression and anxiety.
I have had no bleeding for over a week now (there wasn't much at the start of this flare) apart from yesterday where i think I damaged myself with the plastic tube.
Would be grateful for anyones views on this. Is it worth taking colofac or buscopan for the cramps.

Thanks in anticipation and happy new year to all.

Mad Martha