I've been on 6mp since Jan 2004. I haven't had a flare up since then but do have fatigue issues still. Not as bad as when I was tapering off pred but I don't have the energy I probably should. I also have arthritis and other chronic pain issues and don't sleep well at night which doesn't help fatigue problems. I just try to rest when I feel I need it. Being flare-up free is worth it. I hope 6mp works for you. I know it doesn't for everyone but it's been a godsend for me.