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Question for those who don't respond fast on Humira (Faithmac or anyone else)

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Ulcerative Colitis
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Posted 7/22/2013 4:39 PM (GMT 0)
So, I had my second load this Sat and no significant improvement. How long exactly should I wait before I scrap this med also.

I just want to know because if this one doesnt do much, I wanna go try something else. My nurse that visited that first time, mentioned something like 3 months.

For those that the med didn't work at first then it worked, if that's possible, how long did it took?

If this doesn't work, I have to call symponi and see if it's available for UC in Canada and make the necessary steps to have it prescribed.

 

Posted 7/22/2013 4:48 PM (GMT 0)
I did 3 months with no results. Tried double doses, weekly doses, etc (GI offered double weekly doses and I said it seemed hopeless)...finally gave up and moved to Simponi.

I think Humira works better for CD patients than us UC'ers. But once you stop then you'll probably build up Anti-bodies and not be able to go back to Humira. Maybe you want to throw some Predisone at it first before you give up on the Humira.

I probably have C.diff right now (could have been a while), I have to drop off the sample tomorrow. So my humira & Simponi results may have been compromised. I took a c.diff test in May and that was negative but like I said I think I've had it for a while but now it is getting much worse...ugh.

From my reading of the Forum I can't find too many people with UC who have responded well to both Remicade and Humira, looks like it is most Remicade and sometimes Humira but usually not both (maybe we should do a poll).
Posted 7/22/2013 8:04 PM (GMT 0)
Somedude, how many BMs are you having a day these days?
And are you taking any kind of mesalamine?

For me it's been like 3 weeks since I started Humira and I don't know if it's working well. I have ups and downs but I also started on Nizoral(gerneric) 200mg a day for Cryptococcus fungus.

Apparently on, http://www.askapatient.com/viewrating.asp?drug=125057&name=HUMIRA, there are a lot of people who are having success with Humira. And some say, it took them months to fully take effect.
Posted 7/22/2013 8:06 PM (GMT 0)
How many BM? ...Dude don't ask me this, I stop counting after 40.....:(

After 40, they use a defribilator in my house to re-animate me.
Posted 7/22/2013 8:10 PM (GMT 0)
It doesn't take 3 months for Humira to kick in. People who respond to the biologics usually do so quite quickly; if not after the first dose, then certainly after the second or third. If you haven't responded after the first 3 loading doses (for both Remicade and Humira), forget it, it ain't happening.
Posted 7/22/2013 8:15 PM (GMT 0)
"It doesn't take 3 months for Humira to kick in. People who respond to the biologics usually do so quite quickly; if not after the first dose, then certainly after the second or third. If you haven't responded after the first 3 loading doses (for both Remicade and Humira) forget it, it ain't happening."

OH YEAH?!!? and who asked you!!! I want people to tell me it's going to work so well and to bring me the rose colored glasses. I must have mis-placed them. lol

Don't you worry, I got 2 scripts now. When I get approved for the third bio, I'll use all 3 at the same time! MAX POWER! If that doesn't work, I must have alien immune system, beyond human comprehension.
Posted 7/22/2013 8:16 PM (GMT 0)

Somedude said...
How many BM? ...Dude don't ask me this, I stop counting after 40.....:(

After 40, they use a defribilator in my house to re-animate me.

wdf. you were having 20 BMs like a month ago, and still having that many? If I were you, I probably would have gotten hospitalized already from dehydration, blood loss ,etc
Posted 7/22/2013 8:17 PM (GMT 0)
"How many BM? ...Dude don't ask me this, I stop counting after 40.....:(

After 40, they use a defribilator in my house to re-animate me."

so what kind of job do you have that you can visit the can that many times a day ?

Posted 7/22/2013 8:40 PM (GMT 0)
I kid, I kid...jebus you guys believed 40?, I should have put 60. well to honest, I dont know...10 or so?.....its not so much the number, its the urgency.
Posted 7/22/2013 9:22 PM (GMT 0)
so then you are improving ?

ya, I don't believe 40, but some newbs would -

 

Posted 7/22/2013 9:50 PM (GMT 0)

soystud said...
so then you are improving ?
ya, I don't believe 40, but some newbs would -

improving....seriously bro, I'm not sure what is improving. If I am improving, I am not noticing it. I'm not good with subtleties, I wanna see concrete stuff.

When I'll see concrete stuff, I'll keep you posted. :D
Posted 7/22/2013 9:55 PM (GMT 0)
perception !

if I was going 50% less than I was a month before, I would be pleased - I could do things with 10/day that I couldn't do w/20 -
Posted 7/22/2013 10:07 PM (GMT 0)
I think it does something...how could I put it in a historical context...hmm

something like the Russians not giving up Stalingrad when it the face of defeat.

that's about how it works for me.

I noticed that if I'm off a biologic for an extended period of time, stuff starts turning grim, worse than bad kinda deal.

I'm not on the same measuring scale as you. I measure like this. I feel BAD today. But yesterday I felt SUPER BAD. It's an improvement. Then, the next day it's between BAD and Super Bad. lol

You're on the other end of spectrum. smilewinkgrin

Before this disease, It was like ...good, great, great, good, fair, good.... then after UC, the market crashed, and I went terribad, bad, worse, bad, superbad, bad....
Posted 7/22/2013 10:46 PM (GMT 0)
hmmm go to the hospital for hydration and blood transfusions ? come out with c diff, blood clots, lung infections, etc. keep fighting the good fight, dude.... w/e that means
Posted 7/22/2013 10:58 PM (GMT 0)
" the market crashed, and I went terribad, bad, worse, bad, superbad, bad...."


your bad is another dudes good - perspective ?

but you're right - I don't want either one !

i'm totally blessed to be where i'm at -
Posted 7/22/2013 11:35 PM (GMT 0)
Somedude, I wish UC would knock it off at least some of the time so you could not always have to think about that crap all day :( I wish UC would leave all of our lives lol. Man what it would be like to have your problems be something not poo related. darn normal people!!! I wish some drug would knock your UC on it's ass!!
Posted 7/23/2013 1:20 AM (GMT 0)
I spent 6 months on Humira. Within 4 days it resolved my joint pain & psoriasis. At about the 3rd injection (bi-monthly) I noticed a slight improvement that lasted only about 3 days and then back to my norm. I've heard of some people having luck at one shot a week, but I was never offered it. I really like your sense of humor :)
Posted 7/23/2013 2:44 AM (GMT 0)
Hi Somedude!!!
I felt a little better after loading dose. Not great. It was a gradual thing. I would say about 3 months to really say there was a difference. Then I noticed it was not lasting as long . Into the second week I was feeling not so great. Went on weekly injections, that made a big difference. Now things are fairly good. No real urgency and no blood. I have these hemmies that keep getting irritated.
This September will be a year. I would say give it some time. It's not a miracle drug. I feel a hell of lot better then before a I started . Don't give up so soon! :)
Faith
Posted 7/23/2013 3:00 AM (GMT 0)
Faith- how many BM's a day do you have? Do you have solid stool?
Posted 7/23/2013 3:01 AM (GMT 0)
Look at it this way somedude. You are alreay doing 1000x better than i did on humira!

So that in itself should be applauded.
Posted 7/23/2013 3:14 AM (GMT 0)
ChrissySoul, it depends on the day. Between 1 to 3. Pretty much solid. Don't want it to solid. I have that Hemmie problem. I usually only go in the morning . I'm good for the Rest of the day.
Posted 7/23/2013 3:15 AM (GMT 0)
Faith- that's pretty awesome. Do you get side effects at all?
Posted 7/23/2013 3:15 AM (GMT 0)
Faith- that's pretty awesome. Do you get side effects at all?
Posted 7/23/2013 3:16 AM (GMT 0)
Faith- that's pretty awesome. Do you get side effects at all?
Posted 7/23/2013 3:16 AM (GMT 0)
Faith- that's pretty awesome. Do you get side effects at all?
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