LDN questions

Wow, Aguy. Percocet (Oxycodone) is one of the strongest pain meds known to man. LDN may not do the exact same thing but it is exponentially safer. I realize we all make our own decisions but I would rather deal with some UC side effects over Oxycodone addiction-which does not take long at all. What happens to your UC when you stop taking Percocet? Not good things...

Not trying to be an @ss, so I hope you dont take it that way.

Best...

InSoFla said...
aguywithuc,
Just saw this post.
LDN doesn't block the opioid receptors, it actually binds to them.
That's the reason they tell you that you that the only contraindication to LDN is if you are on any opioids, since both the opioids and LDN compete for the same receptor sites, they would cancel each other out.

Hope this helps answer your question?

Thanks InSoFla, bind/block is the same thing to me. So if it is effective by preventing opioid binding it must be different from the effect of opioids which work by binding to the receptors I would imagine.

protocolteck,

I am not suggesting a lifelong addiction to opioids I did say I was trying to find a similar reaction in the gut receptors 'without' the circus of the vicodin and percocet.

IOW how do you get the same calming effect to the gut without the impact to cognition. I was hoping LDN was it and it is still unclear to me. If having LDN dummies bind to the same receptors calms the gut then I have my answer.

How do you get the 'side effect' only ?

"Opioids increase the amount of time it takes stool to move through the gastric system. They increase nonpropulsive contractions in the middle of the small intestine (jejunum) and decrease longitudinal propulsive peristalsis - motions critical to moving food through the intestines. This results in food that fails to travel through the digestive tract. Opioids are also able to partially paralyze the stomach (gastroparesis) so that food remains in the digestive organ for a longer period of time. Additionally opioids reduce digestive secretions and decrease the urge to defecate."

Those are all positives and if it can be cleaved apart from the mental aspect or if LDN is able to do that then I want to try LDN.

Post Edited (aguywithuc) : 8/12/2013 8:06:52 AM (GMT-6)

Gonk said...
The mechanism by which LDN provides benefit is not understood. The theory was that it would suppress your endorphin levels thereby causing your endorphin levels to bounce back to higher levels, thus boosting your immune system. That was the reason it was recommended to take LDN late in the evening. This was complete theory and has subsequently been debunked.
There is hardly any valid research on LDN as it is off patent, so nobody really knows why it works for some people - for UC or MS or anything else.

Thanks Gonk.

I think from what info I do have I can see that my root cause is an over excited over-active GI tract and all things that calm and slow it benefit my condition.

For now RS diet is keeping things in check but it is good to be analyzing/researching UC.