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Ulcerative Colitis
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Posted 9/17/2013 5:40 AM (GMT 0)
I chickened out of taking 6MP for the past few days...I think tomorrow I'll actually start it maybe. :)

I've been on apriso and asacol HD and neither seemed to work...matter of fact asacol seemed to make me worse. What DOES seem to work is Mesalamine enemas, even though the past few weeks it doesn't seem to be enough, I've had it pretty rough lately....which is why my doc put me on 6mp.

So the question is, do you guys think I should try Lialda just to exhaust the meslamine options before going on to the big guns? I don't feel like I'm INTOLERANT to Mesalamines since the enemas seem to work, maybe the oral just doesn't work for me at all, or maybe it's just apriso and asacol? Or do you think it's a waste of time since two different ones already didn't work, and I should just get it over with and start the 6mp which seems inevitable?
Posted 9/17/2013 6:16 AM (GMT 0)
I was on Asacol before giving Lialda a try. Asacol didn't agree with me..gave me horrible bloating and painful intestinal gas. Lialda has worked well for me, but was on the highest dosage.
Posted 9/17/2013 8:27 AM (GMT 0)
go on the 6mp as you are wasting your time trying different oral meslamines. about the only difference with lialda is it is less pills per day, 2-4 in the am. big pills 1200mgs each. otherwise they are identicle to asacol hd.

6mp takes a while to build up in your system, multiple months. so, no sense in delaying.
Posted 9/17/2013 10:33 AM (GMT 0)
What are your current symptoms? If they are tolerable I would try another brand of mesalamine. I am currently on Colazal. I was on Apriso, but so far Colazal has less side effects for me.
Posted 9/17/2013 11:46 AM (GMT 0)
When I switched from Asacol to Lialda I saw almost immediate improvements but I believe it was more placebo effect than the brand change to be honest. My overall UC has been worse since switching to Lialda, although not because of the switch, just the disease progression. Switching mesalamines wasn't going to thwart that. I am confident the 6mp will be the answer for me. This is the start of my second week on it.
Posted 9/17/2013 12:12 PM (GMT 0)
How you been doing on the 6mp so far Gonk, any side effects?

My current symptoms are frequency and urgency, and some days I feel constipated (even though I go to the bathroom 10-15 times/day) and in a little pain....a lot of nights I also wake up multiple times to go. It's been going on for way too long...so I think 6mp is probably the right choice...
Posted 9/17/2013 1:58 PM (GMT 0)
I have not had any side effects whatsoever from the 6MP so far. I have been on prednisone 40mg for the past two weeks too and so I am pretty much symptom free at this point. I think the 6MP takes a month or two to kick in from what I could gather from the others here.
Posted 9/17/2013 2:36 PM (GMT 0)
I do think Colazal doe not get enough consideration. Unlike most of the other-5asa, it is not a time release. I take Lialda, but have never really had a trial of any other. I don't even know if some residual symptoms are not due to Lialda. I would have to quit to find out. I migh tlike to add some Colazal, and then taper the Lialda just to know more.
Posted 9/17/2013 2:44 PM (GMT 0)
What exactly is the regimen you're doing at this point...meaning what meds and when?

q
Posted 9/17/2013 4:42 PM (GMT 0)
I'm doing Apriso twice a day (morning and night), before I was doing Asacol HD 2 pills 3 times a day but switched to Apriso because Asacol wasn't working after a year and we thought we'd try a different one. I'm also doing Mesalamine Enemas at night. I was also on Uceris for a while but that didn't do anything.
Posted 9/17/2013 5:53 PM (GMT 0)
Have you tried prednisone? Or steroid enemas? I'd consider a course of one/both of those to try to get you into remission before you make the jump to 6MP. I had to use oral pred to get into remission, but I was able to taper off easily and have been in remission (using meds in signature for maintenance) for 4.5 years.
Posted 9/17/2013 5:59 PM (GMT 0)
I have tried pred in the past and it didn't seem to help....I've been in this flare for about 6 months now, I've been on Apriso pretty much the entire time. I'm on a new round of pred that I started on Sun and it seems to be a huge help this time....but I also bit the bullet and started the 6mp this morning. I just want to be back to normal, I've missed my kids first soccer game last week because there were no toilets there and I wasn't doing that great, so I was afraid of going. I really hope the 6mp does the trick.
Posted 9/18/2013 3:39 AM (GMT 0)
Give te 6mp some time to be at a therapeutic level, 2-3 months, while you ween Pred. Doesn't seem the 5asa's are doing it for you. Hope it brings you to a true remission.
It is a drug that can be stopped and started again some day, so it is not a forever decision. Risks are there, but slight compared to symptoms of UC at the level that interferes with soccer games.
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