Iron supplemented diet protects against chronic immune mediated colitis in mice

Now this is strange I always thought iron supplements made me worse,perhaps the type of iron ,or slow release is better.

Depresses total mucosal bacterial load in mice 6 fold and enhances F. prausnitzii.

Old Mike

https://www.ecco-ibd.eu/publications/congress-abstract-s/item/p689-iron-supplemented-diet-protects-against-chronic-immune-mediated-colitis-in-mice.html

then we have this on mouth biofilms

http://medicalxpress.com/news/2013-11-drug-periodontitis-chronic-diseases.html

Post Edited (Old Mike) : 11/8/2013 10:27:51 AM (GMT-7)

lactoferrin is a much better iron builder that also attacks pathogens.

i've had to take iron supplements for years now but have never noticed it helping or hurting my UC. i wish it gave me the constipation problems it gives a normal person. that would be nice.

Ecoli are going after the iron in the inflamed sites.

Now it might also make sense as to why the mice improve with extra iron.

Suppose you flood the colon with extra iron perhaps the bacteria then

don't need to go to the inflammation to get the iron.

Of course you might increase the fenton reaction,and other iron induced ROS.

OM

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637091/

iron ibd trial

http://www.ncbi.nlm.nih.gov/pubmed/16305723

this trial made uc worse

http://www.ncbi.nlm.nih.gov/pubmed/16165718

Post Edited (Old Mike) : 11/8/2013 2:07:26 PM (GMT-7)

Well here is the info from my old iron thread,lots of conflicting info.  Mostly  might seem that excess iron is

not good.

Also conflicting is the 10000 sample paper where I believe that they said the bacterial population is reduced

in the inflamed areas.

I will put this one first, UC induced in a person with iron supplements.

http://www.ncbi.nlm.nih.gov/pubmed/1414340

OM

You will notice today that just about any store bought processed food is fortified with iron and other

nutrients.  Some of the iron is in the form of ferrous sulfate/fumerate,other may be

metallic reduced iron.

Iron is also a limiting nutrient for bacteria.

Are we getting toooo much iron from the diet.

Here is one to start off with,I never saw this one before but it is scary.

Old Mike

http://www.ncbi.nlm.nih.gov/pubmed/18801890

Here is a table from the gov.

http://ods.od.nih.gov/factsheets/iron-HealthProfessional/

Looks like adult females need 18 mg while males need 8.

I serving of 100% fortified cereal = 100% required non heme iron

for an adult female.

Looks like about 10% is absorbed.

What happens to the other 90% I think it goes into the colon,some could go into urine,not sure.

They made me hunt again,looks like the 90% goes out in the poo. So if it is in the poo

then the bacteria can get at it, and it can also cause oxidation.

http://jn.nutrition.org/content/53/3/351.full.pdf

So if you eat a lot of processed fortifed snack foods,you are getting a lot of iron. Natural foods not so much.

In the above water report there only talking about 0.1mg increase,

cant seem to find the absolute amount of iron in the water though.

But one bowl of fully fortified cereal is 18mg.

They made me hunt.It looks like the average is 0.3mg/liter from water,most iron intake is

from food. But this above study was only talking about 0.1mg increase.

http://www.who.int/water_sanitation_health/dwq/chemicals/iron.pdf

http://www.ncbi.nlm.nih.gov/pubmed/10711457

http://www.ncbi.nlm.nih.gov/pubmed/16165718

http://www.ncbi.nlm.nih.gov/pubmed/16133010

http://www.ncbi.nlm.nih.gov/pubmed/16043990

http://www.ncbi.nlm.nih.gov/pubmed/16038040

http://www.ncbi.nlm.nih.gov/pubmed/15235867

http://www.ncbi.nlm.nih.gov/pubmed/12663492

http://www.ncbi.nlm.nih.gov/pubmed/22190022

http://www.ncbi.nlm.nih.gov/pubmed/21558046

Another of real interest,since this population is not eating a sad diet.

http://www.ncbi.nlm.nih.gov/pubmed/20962160

Interesting stuff.

http://sickle.bwh.harvard.edu/iron_absorption.html

fenton reaction

http://www.ncbi.nlm.nih.gov/pubmed/10971233

Post Edited (Old Mike) : 11/9/2013 5:48:29 AM (GMT-7)

Here is the link again,your link does not work right for me.

We have a lot of fortified foods with iron,especially that electrolytic reduce iron.

Seems to be another circle,low iron,bad bacteria mix,supplement it gets worse.

OM

http://www.ncbi.nlm.nih.gov/pubmed/20962160

Actually, vitamin D is the biggest increase - suggested it's a pretty substantial increase. And iron is made more available through indirect means.

Though at the same time now they link some lacto bacteria to obesity!.... Soooooo

I'm picturing my sisters Dog. It spends hours each day just chasing it's darn tail in a circle.

You'll have to google lacto bacteria and obesity, as I didn't save the link. But I'm sure it can be dug up. Also yo can google reuteri or lacto bacteria and vitman D or iron. Though I bet one will find studies showing the opposite as well. The circle theme....