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Brief Article Re: MAP Causing IBD

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Ulcerative Colitis
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Posted 2/3/2014 7:26 AM (GMT 0)
I'm browsing around and found a small article regarding some studies about MAP (Mycobacterium sub-species paratuberculosis) and a doctor initiating studies using a certain antibiotic regimen. Seems similar to the Dr. Borody in Australia.

http://www.emaxhealth.com/1020/cure-crohns-disease-sight
Posted 2/3/2014 1:12 PM (GMT 0)
I really hope research continues on this stuff because it seems to be promising. Being able to detect MAP in a higher percentage of UCer's would go a long way.

I believe some studies have found it in as many as 92% of Crohn's patients. I think if it can continue to be researched MAP will be found to at least one causative factor in a great many UC/CD cases and AIEC (an e. coli bacterium) a great many CD cases.

John Herman Taylor is a professor in London who is developing a MAP vaccine and is trying to raise funding for more trials. His daughter is helping him with the fundraising. Unfortunatley the "Technology Strategy Board" rejected his proposal and request for funds for his vaccine.

/www.facebook.com/RunForCrohns

freeola.com/crohns.php
Posted 2/3/2014 1:17 PM (GMT 0)
And that antibiotic therapy had great results 80% remission in pediatric CD patients.

ir.redhillbio.com/releasedetail.cfm?Releaseid=797192
Posted 2/3/2014 4:09 PM (GMT 0)
cinnamon oil is very active against MAP you have to take it a really long time because map is such a slow grower
Posted 2/3/2014 4:27 PM (GMT 0)
I am less interested in what antibiotics show promise for Chrons as I am in those that show promise for UC. The UC evidence is much weaker, and has less connection to MAP. Still, I wonder if I should try a two week trial of some of the combinations reported.

Abdolghaffari, A. H. A Comprehensive Review of Antibiotics in Clinical Trials for Inflammatory Bowel Disease. INTERNATIONAL JOURNAL OF PHARMACOLOGY, OCT 1 2012. said...


1) Antibiotics when used with 5-ASAs or corticosteroids or probiotics or immnnosuppressive showed better effects than monotherapy.

2) In UC, concrrent use of amoxicillin, tetracycline and metronidazole keeps patients in remission much better than monotherapy.

3) the debate on the use of antibiotics in IBD still remains and need fwther well-designed studies to help identify which patients need antibiotic or antibiotic combination and if yes, what is the preferred compound with what dosage and duration of treatment.

I reviewed the studies in the UC section,in the more recent studies with triple antibiotic, about 1/2 of people see improvement. Only about 35% see remission. Results are better 12months later than 6 months later, so the benefit of the 5-asa and probiotics cannot be firmly discounted.

But, 50% is a little better than the roughly 30% to 42% that has been found for 5-asa alone. Also for steroid-dependent patients, one study found about 19% got remission in the 6 months after 2 weeks of antibiotics. Since these are people who did not et remission on 5-asa alone, and were dependent on pred, 19% is not a bad number.

Clearly it does not help everyone. Only about half, and less than that for remission, and only when used in combination with the usual drugs. Some earlier work found it did not significantly help in severe cases.

It does look like some might be helped. I know my GI would write me these scripts. But recently I had amoxicillin for few days and began to bleed and cramp real bad. Maybe the triple combination would not cause me distress - or maybe (for me) it would be worse.

I an waiting for a photocopy of one of the more recent studies in the review. I want to see exactly what dosage was used before I go speak to my GI.
Posted 2/4/2014 2:20 AM (GMT 0)
@DBwithUC,
How long this triple AB treatment is recommended. I do not have issues about the two, but tetracycline is the one that you need to be careful about. It is also one of those where there are a many of drug-drug and drug-food interactions involved.

BTW, just curious if there is anyone on this board, who has a 'diagnosed' MAP infection. If there is any test to confirm the infection.
Posted 2/4/2014 5:16 PM (GMT 0)
two weeks.

here are dosages:

The trial design was an open-label observational cohort study. A 2-week combination therapy consisting of amoxicillin (500 mg t.i.d.), tetracycline (500 mg Li.d.), and metronidazole (250 mg t.i.d.) (ATM) was administered to patients who satisfied the inclusion criteria. The clinical symptoms were evaluated on a weekly and monthly basis
Posted 2/4/2014 9:03 PM (GMT 0)
I think MAP may the cause of UC and Chrons, just different area's and quantities determine which you get.


Here are some facts I was looking into:

1) Until the mid 1850s, the dairy industry in America revolved
around the family-owned dairy cow, with little sales of milk or other dairy
products outside the family.1

2) In all probability we shall never know who first
described ulcerative colitis; although the disease
was first referred to by name in 1859 by Sir
Samuel Wilks.2


3) 1822-1895 - The Process of Pasteurization is Developed by Louis Pasteur
Pasteur's research demonstrated that harmful microbes in milk and wine caused
sickness, and he invented a process - now called "pasteurization" - whereby the
liquids were rapidly heated and cooled to kill most of the organisms.3


4) Five independent research groups in three countries (USA 7,9,10, Northern Ireland 8,13, Australia 11) have reported that MAP may be capable of surviving commercial milk pasteurization, and thus may be present in the retail milk supply.

Live MAP has been shown capable of surviving HTST pasteurization, as conducted by a commercial-scale HTST milk pasteurization unit, in research conducted in Australia. 4

During this period, milk transitioning into industrialization which perhaps caused an increase in contaminated milk because it was not "straight from cows". Pasteurization perhaps decreased other microbes which could keep the MAP bacteria in a sort of checks and balance scenario. Since the MAP bacteria is able to live in extremely strong conditions, they are able to stay in the gut and constantly produce inflammation. Probiotics give a lot of help to UC's perhaps because they give a small advantage in the gut, but not the correct type of bacteria to fight map. UC being bacteria based makes sense because every time I've taken a medicine that destroys all the bacteria in the gut, I get a short time of remission.




1. http://www.epa.gov/oecaagct/ag101/dairybackground.html

2. http://pmj.bmj.com/content/44/515/684.full.pdf

3. http://milk.procon.org/view.timeline.php?timelineid=000018

4. http://www.crohns.org/map_food/dairy.htm
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