Why Grape Seed Extract, or Oregano Oil might help.

Besides any antibacterial action both are strong antioxidants.

Gary please take note.

But in the case of GSE depending on the dose it can act as a pro oxidant,so that is why you might get

worse on increasing dosage.

Not sure about Oregano oil.

Anyhow based on the radical induction theory-antioxidant action might be why improvement is seen.

Here is the Radical Induction Theory-RIT. I had posted this back in 2012 and it looks quite plausible as

what might be going on in human UC.  Might be real important.

http://www.wjgnet.com/1007-9327/11/2371.pdf

I am still trying to figure out how to up regulate GPx2 which is colon specific, seems melatonin,turnips, dandelion

Selenium, might help.

Trying to up regulate/get more glutathione.

herbs and spices as antioxidants,looks like clove is really high,oregano,thyme,good article

http://www.ncbi.nlm.nih.gov/books/NBK92763/

Here are the old threads,in 3 parts.

Don't miss the part in thread 3,link does not work anymore, some other links might not work.

While re-reading this study I found I missed something very very important.

It seems that chlorination via hypochlorous acid of self proteins can lead to autoimmunity,this makes self proteins look like antigens/ self antigens to the immune system.  This can be limited by trapping HOCl by Taurine.

 working link,cant get pdf link to work.

http://webcache.googleusercontent.com/search?q=cache:5JCTcm0t-wkJ:www.trnres.com/ebook/uploads/elidrissicontent/T_13449429336%2520El%2520Idrissi%25206.pdf+&cd=4&hl=en&ct=clnk&gl=us

Old Mike

https://www.healingwell.com/community/default.aspx?f=38&m=2537173

https://www.healingwell.com/community/default.aspx?f=38&m=2540341

https://www.healingwell.com/community/default.aspx?f=38&m=2543360

 

Post Edited (Old Mike) : 4/23/2014 9:05:19 AM (GMT-6)

These oils do a lot of things that are well proven in a lab

They cause bacterial cell wall to rupture most specifically in Gram Negative bacteria - this has been shown via scanning electron microscope
They tend to leave most "good guys" alone - this has also been shown via the same images
They interfere (down regulate) NFkB inflammatory pathway
They lesson and block bacterial toxins
And as mentioned the structure provides an anti-oxidative compound.

When you think about it, they are made from plants in which they don;t have an adaptive immune system like our with mobile immune cells - it's though each cell possesses the ability to defend itself - and they are bombarded with bacteria just like us - so I tend to think that after a few hundred million years they would be pretty darn good at fending them off.

I think in the paper you posted it said deletion of the gene caused spontaneous Colitis like symptoms - but will have to re-read that to be sure. That's pretty darn interesting cause if that's true they didn't have to induce it by DDS etc. Though it confused me a little as there was a diagram where they proposed a genetic trigger. MTHFR and/or something else was proposed.

Anyway - just want to point out the ROS thing in diabetes.

Post Edited (Canada Mark) : 4/24/2014 10:20:16 PM (GMT-6)

Here is the link to the full paper or his Hypothesis. It's very interesting actually:

Type 2 diabetes as a redox disease
www.scribd.com/doc/210808738/Watson-Type-2-diabetes-as-a-redox-disease-Lancet-2014-pdf

Chemistry is something I have been struggling with and the whole oxidization/reduction thing drives me nuts. I've come to view it as something like this. Let's say a Nitrogen Atom looses a Hydrogen Atom to Oxygen for some reason - in this case the Nitrogen has been Oxidized and the Oxygen has been Reduced.

So it's the same thing as loosing or gaining an electron - just that the entire Hydrogen Atom complete with the electron that the Nitrogen was using, has now been lost to the Oxygen. But the Nitrogen is now highly electronegative so it wants to find another Hydrogen Atom so it can use it's electron and because of this there's this huge cascade of reactions where something that was an antioxidant now becomes and oxidant depending on what's around it. That's my take on the crazy'ness and complexity and the easiest way for me to think about it. So it makes it not quite so complex and a little easier to understand.

EDIT: I don't know if that's right though - just the way I think about it. I think it's right though.

What does that have to do with your paper??? I don't know other than in all these reactions there's a whole bunch of Hydrogen Atoms being shuffled around and well... I HATE chemistry! haha. But I have to learn this stuff.

--------

Anyway, I got to thinking about this Radical Induction Theory thing today while driving around and although it's really interesting and I think quite unique my only issue with it this:

It still implies that either one day we awoke and a gene stopped functioning correctly - or some external chemical triggered a change in our gene. Either way something had to flip a switch and if it's an external chemical why not in everyone. So back to the why me not you thing? Even chlorination in water... why some not others?

On my strange journey to remission one of the biggest things I have struggled with is the realization that food probably has nothing to do with my disease, nor the chemicals added to foods and such in "triggering" it. It's seriously hard for me to admit that though. As well, I have a hard to accepting that I awoke to a wonkey immune system by random chance one day. I do however wonder if the rise in IBD is purely that certain external compounds in our diets and environment make us more "susceptible" to a "something" and of course I like to think of bacteria being that "something".


So all day long while driving I just kept thinking about the bacterial production of Hydrogen Peroxide instead of a genetic aspect to overproduction or food/water chemical additive. So I think I'd like to try and look up tonight to see if any of the bacteria in the 10,000 biopsy paper are major Hydrogen Peroxide producers.

--------

On the antioxidant to oxidant side here is something you might like if you have not already read it.

Symposium: Pro-oxidant Effects of Antioxidant Vitamins
jn.nutrition.org/content/126/4_Suppl/1197S.full.pdf

In fact I think a lot of people might like to read it - it came from a link on Wiki.

Post Edited (Canada Mark) : 4/25/2014 7:43:46 PM (GMT-6)

Oh Mark, you must have just read the paper not my 3 threads.  Bacteria can release just as much hydrogen

peroxide as immune cells.  The 3 threads give a pretty good run down on what might be going on,perhaps our

choices if it is due to bacteria is to ,kill them,change them,or quench them,or all three.

You really need to read all 3 threads to get the rest of the story,I tried to cover much of what is going on.

Also I remember from later threads,if we are not eating RS then we are sort of starving some bacteria,we need

the RS to feed them,then they will start to produce more hydrogen,which will make a reducing atmosphere in the gut.

Also when we get increased NO,then we start to shift populations from strict anaerobes to facultative anaerobes,not a good thing.  Possibly earthing and hydrogen water are not so far fetched after all.

As to why we get this and others don't, possibly epigenetic changes in us,or perhaps we have a weak redox system.

Like you I think why why why,when I was in my early thirties something happened,of course I quit smoking

1977,UC 1980,plus 3 little kids and a lot of job stress at the time.

Old Mike

http://www.jpp.krakow.pl/journal/archive/12_09_s6/pdf/49_12_09_s6_article.pdf

http://ajpgi.physiology.org/content/294/4/G1060

azulfadine and ROS

http://www.ncbi.nlm.nih.gov/pubmed/21208525

Post Edited (Old Mike) : 4/26/2014 11:18:12 AM (GMT-6)