The fundamental basis of inflammatory bowel disease

Here Mike

The fundamental basis of inflammatory bowel disease:
www.jci.org/articles/view/30587

It's a little dated (2007) but a little back and forth between genetic vs. bacterial type thing. One thing that stands out is that it discusses mucosal and bacterial penetration into the tissues and mentions the 10,000 biopsy paper directly- this says it's negative. Or negative into the lamina propria. So just that the bacteria are found at the surface and on top of the epithelial barrier. Personally I don't believe this to be true though - or accurate. I think the author of this particular paper misread Swadinski's study as it's quite clear they stated intracellular. Same with the confocal microcopy paper.

One thing that's clear is one needs to clarify this. Will be interesting to hear back from Swidsinski directly. I'm going to write to the confocal microscopy study author to find out if they also meant intracellular - or the bacteria are intracellular.

What does intrigue me is the antigen aspect - leading back to what Gary says from time to time. So the allergic reaction type side of things.


EDIT: My only issue with a fundamental genetic defect is that we woke up one day with IBD, some of us leading perfectly normal, perfectly healthy lives and then wham!... So something all of a sudden triggered a massive inflammatory response.

Post Edited (Canada Mark) : 7/17/2014 10:34:11 PM (GMT-6)

Interesting

When I first saw the title of the thread I thought you might have found the answer.
The cover a lot of ground,but as usual no answer.

Yet American doc's fail to take into account another possible.

Which is the poison evil theory.

Old Mike

How the hell can UC be auto immune,when 5% of people can go into remission
from the old scope prep,mag citrate. Sort of points to bacteria and their endotoxins,or mucinases. Don't know how long they stayed in remission,dont know if the 5% had a form of
UC that just happens to respond to a clean out.
Never the less,it happens.

Wish I could find that statement again by Borody.
Old Mike

Interestingly, theres the flip side apparently :

www.sciencedaily.com/releases/2011/07/110727204414.htm

But to your point, yes, its not genetic. True some may be more easily prone than others. I have no family history of this. But, I grew up in a stressful household, drank chlorinated (and fluoridated?) water from the tap, drank homogenized, pasteurized, homogenized milk, ate from the basket of agribusiness, etc etc. Who knows what my triggers were.

As far as the farm thing goes, its interesting but people had way less IBD before the invention of agriculture, or domestication of cattle, etc, so it likely has more to do with being outdoors and being exposed to different bacteria, or something.

Sure, we know that. But there's also not a genetic link. The genetic link just might be a susceptibility or maybe were talking about hundred different things that have the same symptoms but for me, I don't think that was too much genetics. Maybe epigenetics that other things brought it out but I think if my life is been different I wouldn't have this.

My point is I just think there's something environmental underlying this and you may have a weaker genetic constitution that makes you more prone, or not. Obviously there's millions and billions of people living like we do don't get this, so we are obviously susceptible to some degree, but I still think it's the environment.

I feel like I have been a canary in a coal mine. We are more sensitive to something(s) and it causes us much distress that the general population does not experience.

As long as I control what goes into my body I have no disease but if I wanted to flare tomorrow then I have a list of foods (?toxins?) that will kick off symptoms if I consume them.