shots from a pill?

Kind of interesting...a little scary.

But wonder if they could create a pill that delivers some kind of shot directly to the colon...

gizmodo.com/would-you-swallow-a-pill-covered-in-needles-instead-of-1641234428

yes it could deliver in the colon. It would simply vary the composition of the pH sensitive coating mentioned. And if the sugar based needles are used, they will dissolve before exiting.

But the need for UC is not clear. Most UC meds act topically. You want contact with not injection through the mucosa. The example mentioned of antibodies, which are large proteins that would be destroyed by the digestive juices - well it is not clear that it has to enter the bloodstream in the colon. Blood circulates quickly.

There would have to be some med that needed to get into the tissue behind the mucosa, or into the small blood vessels of the colon, and it would also be a med that could not be absorbed.

Maybe some biological could be injected into colon tissue in smaller doses than is currently put in through IV infusion. Perhaps this extends the SSI concept, but only using physical delivery. Still I am not sure this is a technology that solves a current UC medication problem.

I think solidification of the turd occurs fairly far along the colon. might make this less useful for proctitis.

ultimately we will take a pill full of nano robots ( http://en.wikipedia.org/wiki/Nanoroboticsthat reach the mucosa in a site-specific fashion ) these will repair barrier, regulate distributions of immune cells and of commensual bacteria.

Possibly they could even be reprogrammed with external signals as treatment progresses.

But this is a ways out