pmitra0123 said...
Thanks - i see you are taking Anti-MAdCAM Antibody - what is that? Is it working?
MAdCAM is a protein on vascular endothelial cells of the GI track. Its what the alpha4 beta7 integrins on WBCs bind to to get into the GI tract. Vedolizmab/entyvio binds to and blocks the alpha4 beta 7 integrins on WBCs while my drug blocks MAdCAM, so they are very similar.
Ive been on the max dose since September and while the inflammation has gone down a fair bit, Ive only really gone from 11-13 BMs/day to 8-11 so not a huge improvement. That being said, Ive been in a constant flare for 5.5 years so there is probably a lot of damage and I may never get much better as it is.