Started Prednisone - Now I'm worse

I've been in a stubborn flare for a few years now. I got it to a manageable level of 9 BM's a day, semi formed. Was able to go out occasionally and have a bit of a life. I haven't been on prednisone in close to 2 years due to side effects, but I figured I would try it again just to get my BM's down to a normal level once again. I've been on prednisone for 2 weeks now at 40mg, and every time I go it's liquid, blood, and I'm in pain. Now I'm going about 11 times a day. Why on earth is this happening? I was going to only stay on 40mg for 2 weeks, but I think I'm going to stay on for another week to see if that does anything. Has this happened to anyone else before?

Have you had a stool test done lately?

I see you have tried cortifoam. Have you tried the Rowasa enemas?

You may need a higher dose of pred if you have been flaring for so long. The second time I took it, I had lessening symptoms but went off of it because it never got me out of the flare and the side effects stink as we all know.

Or your system is no longer responding to pred anymore and your flare is just getting worse as a result of pred no longer touching it...happened to me.

Of course there's the chance you might have c-diff or something as suggested above but it definitely wasn't c-diff in my case, for me it was simply no longer responding to pred. And I too tried it after a few years of not being on it...in fact, each of the 5 times I went on it, it worked less and less for me until finally not at all.

I got C-diff tested 2 weeks ago before I started prednisone, came back negative.

I'm currently in a study. The drug is similar to entyvio, and I've been on it for 8 months. Like I said, I was feeling a lot better than I have been prior to the study so I figured I just needed a boost so that this drug can fully take over and keep me in remission.

Well I was on it for 8 months prior to starting prednisone. I went from 20+ BM's a day, crapping my pants, not being able to leave the house, to 9 BMs a day, no accidents, having somewhat of a life and gaining 20 pounds. So drug is definitely doing something. I just figured I needed a small boost to get me into remission. They study has strict rules on which drugs you can use, for how long, and for length of time. Since I've been on the drug for so long, a short course of prednisone is allowed.

To me it still just sounds like the Pred isn't doing it for you anymore, the same thing happened with me and pred...if within the first 2 weeks of being on 40 mg a day isn't keeping D at bay then I'd say the pred no longer works for you.

I hope they can find something to get you in an even better place than you are now, I feel for you, I spent years having well over 20 daily BM's a day and it definitely sucks rocks!