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Fungus and IBD pops up on here occasionally. New study looking at the double role.

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Ulcerative Colitis
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Posted 6/24/2015 3:21 AM (GMT 0)
Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis.

www.ncbi.nlm.nih.gov/pubmed/26013555

Kind of interesting on how fungi depletion contributed to a loss of butyrate-producing Clostridium XIVa. Actually the whole thing is quite interesting - and not what I expected to read at all...
Posted 6/24/2015 3:28 AM (GMT 0)
As you say quite interesting,everything is bacteria centric it is about time they look more at fungi.
Next thing you know the new probiotic will be spent mushroom soil,2 cubic feed for 5 bucks,bought it
for my garden,but did not eat any.
Old Mike
Posted 6/24/2015 3:37 AM (GMT 0)
Sorry, I read the article but don't have a clue as to what it's saying...so should I be eating mushrooms or not?
Posted 6/24/2015 3:42 AM (GMT 0)
I guess at the end of the day it simply suggests more research should go into the fungal aspects as to how they contribute to the overall microbiome. I always associated fungus with bad... but this suggests that perhaps that's not always the case.

Actually when I read it my mind jumped to fecal transplants. Maybe the transfer of various fungi play a big role in the re-establishment of certain bacterial populations i.e certain clostridium etc.

One day perhaps they will start doing bacterial and fungal change studies concurrently.

EDIT: equally, I guess fungal transfer in FT could perhaps make things worse.

Post Edited (Canada Mark) : 6/23/2015 9:46:35 PM (GMT-6)

Posted 6/24/2015 4:45 AM (GMT 0)

Study said...
Penicillium, Wickerhamomyces, Alternaria, and Candida are increased while Cryptococcus, Phialemonium, Wallemia and an unidentified Saccharomycetales genus are decreased in the guts of DSS-colitis mice. Fungi-depleted mice exhibited aggravated acute DSS-colitis associated with gain of Hallella, Barnesiella, Bacteroides, Alistipes, and Lactobacillus and loss of butyrate-producing Clostridium XIVa, and Anaerostipes compare with normal control.

I wonder how one might go about introducing more numbers of those fungi? In some of the books I've been reading about probiotic proliferation in the gut, most of the time we regrow these things slowly if we've suffered major losses, but some people lose the strains completely... and then things like fecal transplant become more important.

I noticed that when I used to eat yogurt to try and help my UC, it didn't do very much... then I switched to kefir, which contains beneficial yeast, and I noticed more of an impact. Kombucha is another ferment that has beneficial yeast, but I'm not sure if they actually stay in the gut.

I wonder how we'd go about getting more of that beneficial clostridium introduced, aside from fecal transplant?
Posted 6/24/2015 11:21 AM (GMT 0)
Maybe it's why saccharomyces boulardii seems to have a positive effort?
Posted 6/24/2015 6:06 PM (GMT 0)
That probiotic made me worse, instantly, although the reason I tried it was because there seemed to be a lot of good research on this in regards to UC. They often give it to those on antibiotics and I'm almost 100% sure my UC was triggered by broad spectrum antibiotics. It is a yeast which is high in histamines and I am intolerant of "dietary" histamines since coming down with UC. Interesting thread. I think I mentioned in another thread that I thought UC might be an autoimmune attack against a bacteria in our guts (maybe a good bacteria) or fungi or yeasts in our guts, etc.
Posted 6/25/2015 11:09 AM (GMT 0)
I am sure there must be "good" fungus that keeps other fungus in check similar to what has been found for bacteria, I expect we will find the same for viruses too. I think most cultures where mushrooms grow had certain varieties as part of their healing regime in pre-pharma times.
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