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Best IBD microbiome/metabolic study I have ever found

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Posted 7/5/2015 10:26 AM (GMT 0)
Found this in an odd way searching riboflavin mucin.

Still trying to wade through it, very comprehensive,amazing work,never found this one before

Seems gut bug metabolism strongly perturbed, perhaps trying to defend from oxidative stress.

Goes into what is happening with many things to the gut bugs, cd,uc,age,smoking,antibiotics,5asa you name it,stool biopsy samples.

Those into this sort of stuff, might even get giddy.

Here is a for instance.

Amino acid biosynthesis and carbohydrate metabolism are reduced in the IBD microbiome in favor of nutrient uptake.


Looks like this whole mess may have a significant tie in with the radical induction theory and oxygen hypothesis,

was not looking for this but it seems that the tie in is there.

Plus as I read on, it seems that the little buggers are eating more of our mucus.

Actually may have found it before, but good to read again and pay close attention to what they found.

Old Mike

http://www.genomebiology.com/2012/13/9/R79

 

Posted 7/6/2015 1:43 AM (GMT 0)
OM,

I dont have much biology knowledge. But when I think about IBD, My thoughts says both are influenced by pathogens where, Colitis dominated by pathogens those eats mucus but not flesh. May be something lives in plant source. And in Crohns its the pathogens eats flesh. May be something lives in deceased animal. But these are just my thoughts. idea

My first flare was after pregnanancy. But  I had gestational diabetic during pregnancy. I guess it is something to associated with colitis and carbohydrate metabolism ratherthan insulin resistance.

Posted 7/6/2015 11:51 AM (GMT 0)
I perused it and it looks like a fantastic paper! Thank you, Old Mike! I look forward to reading it completely (assuming I'll not understand a lot of it).
Posted 7/6/2015 12:43 PM (GMT 0)
This is sort of a new way at least for me to look at things, it is not just dysbiosis so much, but
the change in gut bug metabolism, what they eat, what they produce,how they feed the other bugs,
how they protect themselves from, immune stress, all in a perturbed cycle, that possibly drives more immune stress. One problem is not all that much is known about what is really going on, so lack of
a lot of info.
I am thinking that reducing the ROS/oxidative burden, make sure you have enough glutathione reductase,
to insure enough reduced glutathione,via riboflavin,which may also provide the gut bugs with extra riboflavin to protect themselves from all the oxygen tension.
If you take enough at least 100mg, possibly might even need 10mg/kg at least in mice to get some to bypass the small intestine and get to the colon.
At any rate if we can lower the stress on the bacteria, they might revert back to normal metabolism,
if we lower the amount of oxygen byproducts in the colon, might allow for the growth of the normal
more strict anaerobes as opposed the facultative ones.
As I said above all ties in with the radical induction theory,not that I was looking for a tie in, but that is where it leads.
Old Mike


Seems that we can learn from industrial processes.

http://aem.asm.org/content/80/9/2833.full

Post Edited (Old Mike) : 7/6/2015 7:09:19 AM (GMT-6)

Posted 7/6/2015 12:54 PM (GMT 0)
Thanks for posting. Was interested to see mention of changed tryptophan metabolism, that could explain a lot when it comes to the fatigue and melatonin disruptions for instance.
Posted 7/9/2015 5:41 PM (GMT 0)
So bottom line, take more B2?
Posted 7/9/2015 6:45 PM (GMT 0)
Seems there are so many dynamic factors involved. With all those confounding variables, it's extremely difficult to nail down cause and effect. There is probably a cascade of cause and effect, with some of the effects causing other issues, and creating a viscous cycle of inflammation.
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