London Lurker said...
Thought that it rung a bell so searched my old posts and found this on a thread I started about probiotics with b. subtilis in them.....
Just been reading a bit more about subtilis. It produces hyaluronan.
aem.asm.org/content/71/7/3747.full Hyaluronan or Hyaluronic acid has been tested a lot for help with osteoarthritis, some helped by it but no conclusive evidence. Just found a study "Hyaluronan Inhibits Dextran Sodium Sulfate-Induced Colitis in a Toll-Like Receptor Dependent Manner" Ling Zheng, Yan Zhang, Terrence Riehl, William Stenson
DSS colitis is what the poor mice get induced in them when they do colitis testing
So - if subtilis is getting killed off, that's one inflammatory substance in the body that you are going to miss...
So seems once again a link to the microbiome...
How confusing, I have 'Doctors Best Hyaluronic Acid' do I not take it ?
HA acts as a promoter of early inflammation, which is crucial in the whole skin wound-healing process. In a murine air pouch model of carrageenan/IL-1-induced inflammation, HA was observed to enhance cellular infiltration. showed a dose-dependent increase of the proinflammatory cytokines TNF-α and IL-8 production by human uterine fibroblasts at HA concentrations of 10 μg/mL to 1 mg/mL via a CD44-mediated mechanism. Endothelial cells, in response to inflammatory cytokines such as TNF-α, and bacterial lipopolysaccharide, also synthesize HA, which has been shown to facilitate primary adhesion of cytokine-activated lymphocytes expressing the HA-binding variants of CD44 under laminar and static flow conditions. It is interesting to note that HA has contradictory dual functions in the inflammatory process. It not only can promote the inflammation, as stated above, but also can moderate the inflammatory response, which may contribute to the stabilization of granulation tissue matrix, as described in the following part.
/en.wikipedia.org/wiki/Hyaluronic_acidThe lower intestine, or colon, may be reactive to these common problems of the upper GI, or may have problems of chronic inflammation that are unique to the colon itself. Research has found that the colon mucosa resected from patients had altered glycosaminoglycans (GAGs), which is related to inflammatory conditions, and these GAGs had a high amount of hyaluronic acid content. This could signify that the body is producing more of this protective acid in response to bowel inflammation, or it could signify an excess that could come from an overgrowth of certain bacteria that have capsules made of hyaluronic acid, such as streptococcus A. Since hyaluronic acid can inhibit our immune responses to inflammatory mediators, or cytokines, and stimulate excess of the various interleukins and lymphocytes involved in the autoimmune responses, this could be a key part of the disease process. An herbal course of treatment that utilizes formulas to counter excess bacterial growth, then restores normal flora and fauna could be a key strategy in treatment.
www.acupunctureintegrated.com/articles/irritable-bowel-syndrome-colitis-and-crohns-disease-ibd/inflammatory-bowel-disease-ibd-crohns-disease-and-ulcerative-colitis