Posted 12/14/2015 8:28 PM (GMT 0)
The shingles vaccination is live. It's not recommended that uc patients on immunomodulators (imuran, 6mp, aza) and/or biologics (humira, remicade) take any form of a live vaccination. I've spoken to a few nurses who've known of uc patients who took a live vaccination and were fine. Certainly, immuno suppressed individuals are more at risk. It's something I'd discuss with your gastroenterologist.
What is a live vaccine? A human virus is put into a nonhuman host for a number of generations where it is allowed change to reproduce more efficiently in its new host. When put back into humans as a live vaccine, that virus is no longer efficient at reproducing within humans. Your immune system has the advantage over a weakened virus, develops antibodies and easily defeats it before you get sick.
In some cases, the weakened virus reverts back to being efficient at reproducing within humans, and with a weakened immune system, we might be in for trouble. It's not common to occur, but that's what they're guarding against when they tell us no live stuff.