I am coming up on 2 years of remission using Isatis Cooling - I still take Apriso and Canasa (as needed). I had a pretty quick positive reaction to it when I started it in a stubborn flare - my acupuncturist had me doing 5 pills/3 times a day until I reached remission, and then I tapered from there. I haven't had any negative side effects that I can think of.
I do continue to work on my overall gut health and do uBiome to monitor my gut bacteria (it's still kind of hit or miss, so room for improvement there!) I only take Isatis Cooling now when I feel flare symptoms start to stir up and it knocks them out each time. I am their biggest fan.
Hope it works for you all!