High Salt Diet and Colitis

Well here is something else to think about.
High incidence of IBD and Scandinavian countries and Faroe Islands,perhaps Iceland.
Salt cod per chance.
Increased TH17 response and reduced T regs response and reduced IL-10 not a good combo.
I don't think I eat a lot of salt but who knows.
At the bottom posted a link to the full paper.
Old Mike


High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.

Abstract

This study focuses on characterizing the effect of a high salt diet (HSD) on intestinal immunity and the risk of inflammatory bowel diseases (IBD). We found that mice on a HSD had an increased frequency of IL-17A producing cells in the intestinal lamina propria (LP) compared to mice on a normal diet (ND). Furthermore, most intestinal IL-17A producing cells were CD4+TCRβ+ cells. A HSD increased the LP T helper 17 (Th17) responses in both the small and large intestines but did not increase the Th17 response of other gut-associated lymphoid organ. Although, HSD did not change the percentage of regulatory T (Treg) cells, HSD significantly inhibit secretion of IL-10 and the suppressive function of Treg cells. Moreover, we found that HSD exacerbates trinitrobenzenesulfonic acid (TNBS) induced colitis, and Th17 response was significantly increased in the colonic LP of HSD TNBS-treated mice compared with the ND TNBS-treated mice. This study demonstrates that HSD stimulates the intestinal Th17 response but inhibits the function of Treg cells. Moreover, HSD exacerbates TNBS induced mice colitis, suggesting that HSD disrupts the intestinal immunity and increases the risk of IBD.

www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=13783

Post Edited (Old Mike) : 12/8/2016 10:24:48 AM (GMT-7)

In the UK supermarkets are busy stripping out most of the salt, sugar and saturated fats from ready made meals, cereals, etc. I have a saltier tooth than I used to and find myself adding salt to more and more foods.

Bit like iPoop, I seemed to do better when I had a really rubbish diet, as opposed to just a half rubbish one. At least I didn't get Crohn's. I then got to grips with the concept of "vegetables" and "fruit"; while my diet was still far from perfect it was a lot better than it was - and I still got Crohn's, so go figure.

How much salt was around 12,000 years ago? Everyone bangs on about today's diets, but Crohn's apparently came on the scene with the advent of agriculture and first food crops.

healthcare.utah.edu/publicaffairs/news/archive/2011/08-05-11_CrohnsGuthery.php

Actually it was the neanderthals' fault! I always knew there were some suspicious throwbacks in my family.

www.bionews.org.uk/page_392577.asp

imagardener2 said...
Your article about hitchhiking genes reminds me that Africans who survive malaria due to genetic protection may also have high risk of sickle cell anemia.

This sounds familiar, so I must have read about this somewhere. Evolution definitely isn't always favourable to us, that's for sure - basically, an adaptation that may be great for the group as a whole may be rubbish for an individual.

It's interesting what you said about diabetes not always being down to poor food choices. My 81-year-old dad has consumed more sugar than anyone else I know: his cups of tea resembled that scene from The Fly where the love interest asks Jeff Goldblum if he would like more coffee with his sugar. And yet he's never developed diabetes. Even me, I eat quite a bit of sugar but my blood sugar has always been sound when it's been tested - even when on IV steroids.

There is definitely at least partly a genetic component to diabetes (and all the other 'modern' diseases of society).

"Lucky me, something like 2.9% of my genes are Neanderthal."

I was in the mid/low 3 percent range, 22andme said i was in the 96th percentile (i have more neanderthal dna than 96 percent of 23andme users do). I wish i got grades like that in school, but then again perhaps those caveman genes explain that too... DW was like yeah i already knew you were part caveman that report just verifies it lol.