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research on Nissle 1917 (Mutaflor)

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Ulcerative Colitis
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Posted 12/18/2016 4:14 AM (GMT 0)
I am curious to know what the members of the forum think about this study "Use of Escherichia coli Nissle 1917 producing recombinant colicins for treatment of IBD patients"

https://www.ncbi.nlm.nih.gov/pubmed/27372848

It argues that the largest proportion of people with UC are infected with Adherent-Invasive Escherichia coli strains.

So first--is that true? Has anyone heard of this?

The study goes on to say that "the application of E. coli Nissle 1917 strain as a carrier for specific recombinant colicins against AIEC strains, could probably cause a long-lasting remission of inflammation in CD and UC patients."

I am hopeful--that would be great if some iteration of Mutaflor, modified to carry colincins (whatever they are!) could be helpful. But I am also a little suspicious. The article has 1 author and is published in "Medical Hypothesis".

Thoughts?
Posted 12/18/2016 3:20 PM (GMT 0)
Mutaflor has been discussed here and other places online. The biggest obstacle is AFAIK it is not available in US and not shippable from Canada due to FDA. It also has a relatively short shelf-life so can't stock up on it (if you are driving distance to Canada for instance).

It is considered a probiotic and some people had a good experience with it and others did not, usual for different probiotics.
If it were easily available I'd give it a try since probiotic VSL#3 has been helpful for me.

And yes I'm on the side of people who think my UC is related to bacterial imbalance, whether due to an infectious agent or the good bacteria got killed off possibly with antibiotics and now am low on good/high number of non-good bacteria.
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