Dietary Creatine as a Possible Novel Treatment for Crohn’s Ileitis

Now this is quite interesting, never looked into this.
I am not sure of the dosage though is this 1 gram a day or 1034 mg a day or what,
the way they have is written is 1,034g/day. Like 2 pounds or so.
Looking at creatine dosing it is probably 1 gram.
It pays to search a few ways on pubmed, I normally search colitis, but once every few
weeks will search inflammatory bowel, if I just searched colitis would not have found this.
Old Mike

complete article

/www.ncbi.nlm.nih.gov/pmc/articles/PMC5171926/

guess I should look into this more
mouse studies
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3856803/

too much or even some can be dangerous -rhabdomyolysis
www.medscape.com/viewarticle/405777also

also another caution pulls water into the muscles then causes dehydration
in the rest of the body, need to drink extra

possible paleo diet connection
/www.ncbi.nlm.nih.gov/pubmed/26874700

clinical trial-looks like it is important enough to have a small trial
/clinicaltrials.gov/ct2/show/NCT02463305

now perhaps I can see how only one gram of extra creatine can tip the balance

The daily Cr requirement for an average 70-kg adult male is approximately 2 g, up to half of which may be derived by intestinal absorption from dietary sources such as meat, fish and other animal products [16]. The remainder is synthesized de novo from arginine, glycine and methionine by a two-step enzymatic reaction, utilizing arginine:glycine aminotransferase (AGAT) to generate guanidinoacetic acid (GAA) predominantly in the kidney, followed by hepatic methylation of GAA via guanidinoacetate methyltransferase (GAMT), using S-adenosylmethionine (SAM) as a methyl donor [17]. Cr biosynthesis accounts for ~70 % of the total utilization of labile methyl groups in the body, with SAM availability governed by levels of folate, vitamin B12, vitamin B2 and one-carbon precursors such as serine, histidine, tryptophan and choline [18, 19]. As such, deficiencies in folic acid and/or vitamin B12 are proposed to undermine GAA methylation and impact Cr biosynthesis [20]. Dietary and endogenous Cr enters systemic circulation and is actively transported into multiple tissue compartments by a transmembrane Na+ and Cl− -dependent creatine transporter (CrT), encoded by the SLC6A8 gene [21]. Approximately 1.5–2.0 % of the total Cr and PCr pool is degraded daily via simple non-enzymatic chemical dehydration to creatinine, which is lost from cells by diffusion and targeted for urinary excretion [22].

creatine kinase and inflammatory disorders
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4987751/

metabolic regulation barrier function
www.tandfonline.com/doi/full/10.4161/21688362.2014.970936

monohydrate vs hydrochloride
in the first paper the patient was using the hydrochloride
/www.kagedmuscle.com/blogs/science/85398979-benefits-of-creatine-hcl

Post Edited (Old Mike) : 1/7/2017 10:21:54 AM (GMT-7)

EWA: If you eat meat you get about 2 grams a day, also it is made in the body.
So low does probably ok, there is some indication of high does might cause problems.
Some body builders take quite a lot.

Another interesting question is how did only 1 gram help the guy in the paper.
Unless they got there amount wrong.
In the clinical trial they will be given 21 grams a day.
I wonder if we will ever see the results or will it be buried.
Old Mike

Yes, John. It is most commonly used as a kind of pre-workout supplement.

Just took my first 0.5 grams dose of creatine hydrochloride 1/8 teaspoon,will see
how my gut likes it,or not.
That is like eating 1/4 pound of steak so hopefully no adverse events.
Also been eating as of two days ago lots of lemon peel with some pulp, whatever I happen
to cut off. Most of the flanonoids are in the peel.
Been about 5 hours now and just had 12 oz prime rib, no adverse events yet.
Must be the VO,or the IPA keeping me ok
Old Mike

Post Edited (Old Mike) : 1/14/2017 4:46:49 PM (GMT-7)

Thanks EWA, I know about the pesticides, may go organic if I see any improvement from
the flavonoids.
OM

Mark, good to know you gut likes it, that is like eating 2 pounds of steak.
Another interesting tid bit, remember all those huge methyation threads we had in the past.
Well in order to make endogenous creatine the cycle uses SAMe which methylates, depending on
the source I read between 40%-70% of the available methylation from SAMe is used in the body
to make the one gram of creatine a day.
Creatine supplementation lowers the endogenous synthesis, which I suspect leaves
SAMe free to methylate other stuff. Who knows, might be another aspect as to why
it might work.

I remember many were taking methyl B12 and methyl folate, both of which destroy my gut.
Anyhow this seems a way to increase methylation,by not using up SAMe.

Old Mike

www.benbest.com/health/Meth.html

But according to this hypermethylation is going on in UC,so perhaps not a good idea.
I dont know if have extra methyl groups available will lead to hypermethylation.
/www.ncbi.nlm.nih.gov/pmc/articles/PMC3982627/


one of my old threads


www.healingwell.com/community/default.aspx?f=38&m=2537660

Post Edited (Old Mike) : 1/16/2017 7:08:54 AM (GMT-7)

I just read this article that came out February 1, 2017 about the gene that protects against inflammatory bowel disease has been identified.

https://www.sciencedaily.com/releases/2017/02/170201150622.htm

In the article it said in mice that had similar symptoms to IBD due to the recessive Gatm gene mutation - "Those symptoms improved when the mice received creatine in their drinking water, the researchers said. The study indicates that creatine is necessary for providing the energy needed for the rapid replenishment of the mucosal barrier."

So I'm gonna give Creatine a try.

Thoughts?

Will do Old Mike. I took it years ago for working out before I had UC. Will definitely be cautious (as I always am when trying something new) and will let you guys know if something good happens.

Steve