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BPC 157 Supplement for UC?

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Posted 4/4/2017 6:41 PM (GMT 0)
Thanks to Csantamaria who referred to a supplement worth trying I think I'm going to try it out. It's called BPC 157. Just wondering if anyone else has any information about this supplement or experience in using it?

It's a peptide that seems to have anti ulcer properties in the upper and lower gastric tract. Found the following link:

https://www.ncbi.nlm.nih.gov/pubmed/22300085

"Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-system, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1-A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157's high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used on a long-term basis."
Posted 4/4/2017 9:09 PM (GMT 0)
Sounds interesting. did you find a source for it?
Posted 4/4/2017 9:31 PM (GMT 0)
Struggling to find out where it can be purchased from.... wonder if Csantamaria knows of a source?

From what I've researched a lot seem to use it for healing injuries relating to tendon and ligament damage.
Posted 4/4/2017 9:51 PM (GMT 0)
From what I've researched so far it is in research and not to be sold for human consumption yet unless anyone else on here knows any different.

Found some more interesting articles about it though:

https://link.springer.com/article/10.1007/s00595-006-3498-9

http://www.sciencedirect.com/science/article/pii/S0928425797894806

https://www.ncbi.nlm.nih.gov/pubmed/21548867

"Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, M.W. 1419, PL 14736) and wound healing, stable in human gastric juice and has no reported toxicity. We focused on BPC 157 as a therapy in peridontitis, esophagus, stomach, duodenum, intestine, liver and pancreas lesions. Particularly, it has a prominent effect on alcohol-lesions (i.e., acute, chronic) and NSAIDs-lesions (interestingly, BPC 157 both prevents and reverses adjuvant arthritis). In rat esophagitis and failed function of both lower esophageal sphincter (LES) and pyloric sphincters (PS), BPC 157 increased pressure in both sphincters till normal and reduced esophagitis. However, in healthy rats, it may decrease (PS) or increase (LES) the pressure in sphincters. It has strong angiogenic potential, it acts protectively on endothelium, prevents and reverses thrombus formation after abdominal aorta anastomosis, affects many central disturbances (i.e., dopamine and 5-HT system), the NO-system (either L-arginine and L-NAME effects), endothelin, acts as a free radical scavenger (counteracting CCl4-, paracetamol-, diclofenac-injuries) and exhibits neuroprotective properties. BPC 157 successfully heals the intestinal anastomosis, gastrocutaneous, duodenocutaneous and colocutaneous fistulas in rats, as well as interacting with the NO-system. Interestingly, the fistula closure was achieved even when the BPC 157 therapy was postponed for one month. In short-bowel syndrome escalating throughout 4 weeks, the constant weight gain above preoperative values started immediately with peroral and parental BPC 157 therapy and the villus height, crypth depth and muscle thickness (inner (circular) muscular layer) additionally increased. Thus, BPC 157 may improve gastrointestinal tract therapy.
PMID: 21548867"
Posted 4/5/2017 10:24 PM (GMT 0)
i've just read about this peptide on the Polish fora and everybody is wondering why it is prohibited from sale if it is supposed to be such a miracle med? i don't understand it either
Posted 4/5/2017 11:14 PM (GMT 0)
Do a search on http://www.longecity.org and I am sure you will find threads (I just glanced). The people on this forum are very resourceful and into everything and this sounds right up their alley.
Posted 4/6/2017 2:06 PM (GMT 0)
Ewa, that's interesting it's being talked about elsewhere. I am also confused why if it's a supplement consisting of amino acids with said no side effects why it isn't sold other than for research purposes?

Boris_badenof thanks for the link, will take a look now.
Posted 1/31/2018 5:45 AM (GMT 0)
Here is a thorough article on BPC 157. I purchased and will report back how it worked.

(URL removed as we do not want links to retail sites selling products, against forum rules and spammy.)

Post Edited By Moderator (iPoop) : 1/31/2018 6:46:07 AM (GMT-7)

Posted 2/14/2020 5:38 AM (GMT 0)

timetoheal85 said...
Here is a thorough article on BPC 157. I purchased and will report back how it worked.

How did it work? I'm interested in trying BPC 157 and would like to know your experience. Thanks!

Posted 8/2/2021 12:39 PM (GMT 0)
This thread is over 4 years old but it shows that it has promise for helping the entire gastrointestinal tract. Has anyone here tried it?
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