Pathology report need explanation

You have rectal inflammation with cell structure changes that are typical with UC or CD. Great to hear all above the rectum is good and no dysplasia anywhere.

Sig area doesnt mean you didn't have inflammation there....it just means now you don't and it wasnt long standing to cause structural changes as in the rectum has.

Acute can mean obvious inflammation , not only as new. Ive had that on my reports on the past.

So, are you on rectal meds at this time?

q

"For all the samples from the colon at 20 cm, 30 cm, and right colon it says, "benign colonic mucosa without sig inflammatory change. no evidence of dysplasia." This sounds like colon is completely normal to me, correct?"

Yes.

"Biopsy from the rectum at 10cm: "show marked acute and chronic inflammatory change. Crypt abscess formation is noted. Areas of crypt dropout and distortion are noted. Findings are consistent with chronic active inflammatory bowel disease, most likely UC. No evidence of dysplasia."

A normal large intesting has peaks and valleys on its surface like waves on a pond, the valleys are known as crypts in medical jargon. Crypts are of particular interest in UC diagnosis as they get filled with junk that doesn't belong there, clogged with immune cells (crypt absesses). With UC, the crypts are often distorted in shape, their pattern broken, and tissue grows over them creating empty pockets below the surface (crypt dropout). All of those things are permanent architectual changes characterist of ulcerative colitis.

Areas of inflammation are classified as acute when there are no crohnic architectural changes present, chronic when architectual changes are seen. Active inflammation is untreated areas.

I think marked means is noted as obvious.

q