Constant leg pain and headaches for 2 weeks

When I hear about leg pain with Ulcerative Colitis patients, the thing I worry most about is blood clots. We're especially more prone to getting Deep Vein Thrombosis (DVT). I'd have a doctor or nurse check you for a clot, if that hasn't already been ruled out.

Is there any swelling in your leg in the area that it hurts?

is the pain coming from a joint? As that could be a form of arthritis (joint inflammation that can occur at any age) which we are more prone to get.

Both legs or one leg? If it's both, it's less likely to be something like a DVT.

It could be a weird reaction to the Humira. Same with the headaches.

See if you can get a blood test to check for antibodies to Humira (although the lack of antibodies doesn't exclude these things from being Humira side effects).

When was the last time that you were on Prednisone? What was the dose and how long were you on it for?

I just got off prednisone for like the 5th time last week. This time around I started off at 40mg and tapered down, so that lasted about a month maybe a little longer.

I originally was only doing humira every other week, but then I started doing it every week in May which is when they added on imuran.

Headaches and body aches are signs of steroid withdrawal. Especially since you just discontinued pred last week.

Your adrenal system goes to sleep while you are on prednisone. Your adrenal system produces cortisol and prednisone is a synthetic cortisol. When your body is flooded with pred, there is no reason to produce additional cortisol. Cortisol regulates our body's natural sleep cycle (highest in the morning to wake us up and lowest before bed to help us sleep). Cortisol is a mild pain reliever taking care of small aches and pains we have within our bodies. Consequently if you have zero pred and zero cortisol within your body you can be very fatigued, have body aches, have a messed up sleep cycle, etc.

A week in, your adrenals should be functioning again, if not then soon. I'd contact your gasteroeneroligist if you do not feel normal in another week or less.

Some times reintroducing pred at low dosages, and alternating doses (up a bit, down a bit, up a bit, and down a bit) can coax the adrenals back awake, and you would slowly go down to zero pred with normal cortisol levels. In some cases we need to see an endocrinologist-specialist doctor to measure our body's natural cortisol levels, and get our adrenals functioning again back at normal levels.

Throwing up is a withdrawal symptom too.

Well this is actually my 2nd doctor, and he's suppose to be the best or one of the best here. My first doctor was complete crap, so I switched to my current one in February I think. He's definitely more concerned with getting humira to work for me...just did a reload right before I got off prednisone this last time.

So he put me back on prednisone 30mg after about two weeks of being off because I felt 100x worse being off of it than on. So it was 6 pills for a week for the 30mg, then 4 pills for 20mg a week, then 2 pills for 10mg a week, then the last week was 5mg so just a pill. So which is weird because I've usually gone down by 5mg each week, but he really wants me off prednisone

I know I originally said it was 40mg but I went back and looked

I do. I go to MUSC which is the medical university here in South Carolina. I honestly don't think I've been off prednisone for more than a month since I was first put on. My first doctor was at my local GI office, and he put me on humira. He said pretty much the same thing that people had the best response to humira. So now even though humira has not been doing crap...my current doctor just told me to go up to 2 shots weekly instead of just 1 weekly I'm doing now. They said if they chose to stop humira, and do something else that I could not come back to humira in the future. Which is why they are exhausting every option with humira.