Effect of split dosage of Prednisone

It is my understanding that the body produces cortisol mainly in the am. My prednisone has been split between morning and evening. Would I get withdrawal symptoms from going down slowly in the evening dosage, or just the am one? Also, colitis wise, does my split dosage act more like the total amount or the amount for each half?
I am at 7.5/7.5 mg. Last week I was 10/7.5, and I felt fine.

Hi Spring,

The half-life for prednisone is about 4 hrs (time it takes for half the pred to be metabolised.) It takes about 16 hrs for pred to leave your system.
They use split doses to keep the levels high around the clock, which reduces the inflammatory response but keeps us awake!

The body has around 10mcg of cortisol in the morning, and this drops to almost zero by bedtime.
(Around 5mg of prednisone is considered a replacement for the natural amount of cortisol produced in the body. This is used for people who don't make their own cortisol.)

If you haven't taken pred for more than 2 weeks it doesn't generally stop the normal adrenal production. So, people can stop fairly abruptly if they have had a short course.
Beyond 2 weeks the body stops its own production, so you need to taper carefully to ensure the body recommences production.

Reducing the evening dose first helps with sleep. Taking all the pred in the morning also helps.

Everyone metabolizes differently, but that is the general pattern.

I've never had a doctor prescribe a split dosage. The reason it is taken in the a.m. is to reduce the side effect of insomnia.

My Dr had me split my prednisone dose to help the side effects not be so extreme. It did help with that but overall, it didn’t really put a dent in my UC symptoms. What number infusions of Entyvio are you on? I did 3 and had no relief. After 12 weeks of being on it, and getting sicker every day, I opted for surgery. It was a good choice for me. I was soooooo sick. Since surgery, I’ve gained back the 30 lbs I lost and even started running again. Hopefully the Meds work for you. That would absolutely be ideal but if not, don’t get discouraged. Life can still be beautiful!