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Posted 2/28/2019 3:00 PM (GMT 0)
I was on Pentasa granules (2g) for 5 months and my GE decided to make me go back to Pentasa suppositories because of some heart palpitations I had been having. However I am feeling much worse. I get nauseated almost everytime I eat, I am more bloated and started having loose stools again. When I was on the granules I could eat pretty much anything I wanted and not feel like this at all.

Should I report this to my GE and get back on the oral meds?
Posted 2/28/2019 3:55 PM (GMT 0)
Yes, please contact your doctor. You should not be afraid to contact your doctor whenever you are worried about your symptoms or meds.
Posted 2/28/2019 7:04 PM (GMT 0)
Heart palpitations happen for various reasons. Did he send you for testing?
And do they happen all the time?

Call him back and discuss options. Did he take you off the granules and now you're only on the supps?
q
Posted 2/28/2019 11:19 PM (GMT 0)
We're the palpitations confirmed by your doctor? Trapped gas can mimic palpitations.
Posted 3/1/2019 12:27 AM (GMT 0)
Yes I have confirmed extrasystoles in but my GE did not link it to Pentasa. He did refer me to a cardiologist though. Right now just doing rectal Pentasa but feeling it’s not enough. The palpitations have not subsided completely after leaving the granules.

Post Edited (anag26) : 2/28/2019 5:33:40 PM (GMT-7)

Posted 3/1/2019 1:29 PM (GMT 0)
Mesalamine has a rare side effect of heart inflammation, listed as Myocarditis/Pericarditis within the warning sheet included with the med. It is one of those things that happens infrequently enough that your gasteroenteroligist practice might not have had any patients with this problem in the past. So, it is important to mention this potential effect and ask for diagnostic tests to prove/disprove this possibility (typically a chest xray). To be clear, I am not recommending you cease your medications without doctor approval, as this is only a possibility, and a small one at that, but worthy of exploring.

In the event this is an adverse reaction from the mesalamine, then you'd have to switch to another non-mesalamine medication option to treat your UC. Discontinuing mesalamine would stop any medication-induced related heart inflammation within a few days of ceasing that med.

A couple articles discussing this possibility:

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc5242279/

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2943131/

Post Edited (iPoop) : 3/1/2019 6:34:33 AM (GMT-7)

Posted 3/1/2019 6:14 PM (GMT 0)
Probably in your best interests to ask your doc for alternative such as steroid enemas so that you aren't on mesalamine at all.

It might not be linked but you are best to stay off it till you see the specialist.

Keep us updated.
q
Posted 3/1/2019 11:48 PM (GMT 0)
Thank you for your advice. I’ll get in touch with my doctor soon.

I’m still failing to understand something. If my UC is confined to the rectum, why do I feel bloated and nauseated if I’m not in the granules? Why is the rectal Pentasa not enough? Should I be changing my diet rather than my meds ?
Posted 3/2/2019 5:40 AM (GMT 0)
Because you're flaring. How many times a day do you have bms?
Loose as in diarrhea? And were you having harder stools before going off the granules?

q
Posted 3/2/2019 4:41 PM (GMT 0)
The rectal meds make me go to the toilet 2/3 times a day mostly to expel what is not being absorbed. I feel that they contribute to my bloating as well. I had diarrhea twice in the last 2 weeks but I feel i might be having mucus as well when it’s solid (not blood though). Honestly sometimes I find it hard to tell if its mucus or simply the pentasa.

For 5 months on the granules I maybe had diarrhea only once and the rest of the time my stools were fine.
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