Posted 3/25/2019 5:40 AM (GMT 0)
Sigh. After being intolerant to mesalamine (migraines galore), and then developing Humira antibodies, I thought I had been doing pretty well on the Imuran + Inflectra route, even after kicking up my Inflectra to 10mg/kg. I hadn't had much in the way of any symptoms for months and months, and felt like I had gone back to normal. about a month ago, I had a few days of blood, so my GI had my inflammation and Inflectra levels tested and what do you know! 8 weeks out and my levels were non-detectable. Yep, my body ate that crap up and spit it out. I also had a really high inflammation markers, so the GI said it is just a matter of time before I go back into full flare mode. I know I'm on my way there because I am super constipated for days on end, so I know I have some proctitis going on.
Right now, we're trying to decide whether to drop my dosing to every 4 weeks, switch to Entyvio, or maybe try Simponi or Cimzia. I'm not sure where to go from here. I've tried two anti-TNFs at this point and they both are not doing their job effectively. Should I just give up and go to Entyvio? I'm not super concerned about being able to give myself an injection vs. going to the infusion clinic every 8 weeks (4 weeks makes me less happy), as my insurance covers 100% if I go in, whereas I have to pay some mad cash for the injections. I can also get the time off work to go in. We are not yet in Xeljanz land.