Rectal Tacrolimus

Just thought I would share my experience with the drug. So I started to flare in Nov 2019 and my C-Scope showed just 3 cm of rectal inflammation. So my GI prescribed rectal tacrolimus ointment after I failed canasa and Uceris foam. The only hick up for some out there may be it has to be made at a compound pharmacy which thankfully the University of Minnesota has.

Anyway it worked within 2 weeks and I have been doing well since. Maybe an option for those who have distal (rectal only) inflammation.

Cheers!
-Ben

I've heard a few cases of Tacrolimus being used in novel/expiremental ways including Tacrolimus Suppositories. First time I've heard of a Tacrolimus Rectal cream, but suppose it would act the same. Tacrolimus isn't broadly used and the data isn't strong for it's effect. However, a few successes posted over the years here.

but when you go off these enemas, does the inflammation come back? I'd assume it's like prednisone.