Still bleeding and now mucus

Hi everyone.

Im feeling very lost right now. I had been on retention enemas since last November until January due to calprotectin rising. Had no blood or mucus at the time.

Transferred over to foam enemas nightly and budesonide in February due to the inflammation being last 4cm.

Still wasn’t helping after a month and I asked for suppositories instead due to pelvic floor issues with holding in enemas. Urologist gave me tranquilizers for that too which Ive been on for 2 months.

about a month and a half ago I started bleeding, colorectal surgeon saw me and said the blood was a cut probably from inserting the enema incorrectly. Gave me Flagyl that completely destroyed me and I still have diarrhea some days 3 weeks later.

He saw me again, had a look and said no hemmies and the cut had healed, didn’t see signs of inflammation. I also didn't see blood because every time I went it was diarreah.

Continued with supps and started seeing bleeding again last week, went back and he said no hemmies or cuts and is probably the colitis. 4 days later Im still bleeding and for the first time in a long time, I went today and only mucus came out... so now Im even more worried.

I go 2-3 times a day usually. Ive been on Imuran for 2 years. Pentasa since late august, recently changed to 4 big pills a day vs the pellets, 1.2 each pill. Also on clipper 5mg x2 daily for 3 weeks now (type of steroid).

Im very frustrated because I don’t understand how I still have inflammation after so many months of rectal therapies + all the other pills.

Do you have any advice?

Thanks
1Wish

Hi Quincy,

So the colorectal surgeon performed a rectoscope in the office the first time, which detected the cut he thinks from the enema and was worried of infection so gave me flagyl which gave me diarrhea for 3 weeks which probably helped in healing the cut as no solid bm was passing through.

A week later he did it again and saw the cut had healed and said he even saw no signs of inflammation.

Fast forward about 10 days and I had to see him again because I started bleeding again and he did the scope again and said no cuts, no hemmie but the mucosa looked a bit inflammed therefore he reckons it is the colitis and said to mention foam enemas again to my GI next week.

If I do have to go back I guess I will have to be very careful..

I didn't know there were steroid suppositories.

Im worried about steroid suppositories and enemas since I saw on here the post about how it can permanently thin the colon walls.

My original diagnosis was pancolitis and recent rectoscope by my GI said it was limited to 4cm. That was about 2 months ago.

I usually have bms in the morning. Thing is, if I have the supps nightly I usually will go in the morning but lately its been loose and I go couple times morning and maybe afternoon, this is since taking the antibiotics.


If I dont take a supp, some days I dont go, Im never frequent or always go at the same time. Its like I go from multiple to constipated quite often.

Last couple of days Ive started to notice intestinal noises.

1Wish

Post Edited (1Wish) : 3/20/2021 3:31:46 AM (GMT-6)

Yeah Ive been with my GI for years, it was her that referred me to the colorectal surgeon to determine where the blood was coming from as it was suspected hemorrhoids, turns out it wasn’t.

Had plenty of colonoscopies, last one she did was a sigmoidoscopy and determined 4cm inflammation

Hi Quincy. I mentioned the steroid suppositories to my GI but it seems in Spain those don’t exist. Just the foam enemas.

Anyway my recent calprotectin is 505 up from 400 a month ago so now I have a colonoscopy on Monday.

Back on the 4g retention enemas at night and budesonide foam in the mornings until then and after my GI takes a look, will let me know what to do..

Oh I hope Im not awake, looking forward to the fuzzy sounds and then zzz, Ive had about 5 now and I remember the first one where I was sedated but still kind of awake and could feel the air and tube move around. Not nice!

I will get the pics after though.

Hopefully it will be a good diagnosis.

Cheers

I had some blood before but the abx definitely messed me up. In fact almost a month after Im still having diarrea everyday.

I was starting to get sort of solid again last week, then my GI put me back on Salofalk enemas and Budesonide foam in the mornings. Ever since starting I have diarrea again.. I don’t know if its that Im reacting bad to the enemas, still bad from the abx or is the colitis...

When I put the enema in, I can hold it and sleep no problem.. I understand that means theres not much inflammation? Or maybe I just got used to it...

I’m one of those who doesn’t tolerate flagyl well. It makes me extremely nauseous and sickly to where I can’t eat. I refuse to take it orally any more. Unfortunately I am prone to diverticulitis attacks. Previous one dr put me on levaquin and the last one it was Augmentin.

Discuss with your gastro doc before the scope that you've had diarrhea since the flagyl, and that the enemas haven't helped at all. Ask him if biopsies would show if you have a bacterial infection.

Hope prep went OK....let us know how tomorrow goes.

q

Have you been tested for C diff?

Thanks for the update.

It's great all above the 4cm is without inflammation.
What exactly were your biopsies pathology throughout?

It doesn't seem match your bm consistency... wonder if you cut out the Omega (if you're taking it?), added probiotic and low amount of fibre supplement?

q

Hi, so today I had a solid BM this morning with a gentle push and loads of blood, dripping and all. I saw my GI also this afternoon and she said I should do a Prednisone taper, start at 30mg for 5 days, then 20mg for 5 days, then 10mg for 5 days and then back onto the other type of steroid called Clipper which is 5mg until I see here again in 3 weeks.

The idea is to hopefully get me out of this flare by jump starting it via Pred since the rectal meds are really doing nothing.

I was a little worried about Prednisone and the current covid situation but she said I shouldn't be worried and its only going to be for 15 days.

Wish me luck,
1Wish

I will bear that in mind about seeing improvement before tapering, she recently did a colonoscopy therefore I believe she doesn’t think its that bad even though I drip blood hence the quick taper.

My maintenance meds are azathioprine and mesalazine and the nightly 1g Salofalk suppository.

Hi, looking for some opinions as I cant get in touch with my GI today, I’ve been tapering prednisone from 30mg, tapering every 5 days and Im on my last day of 20mg today and supposedly going to 10mg tomorrow.

I have had no blood for the past 4 days BUT today at the end of the BM I did... some drips and on the toilet paper..

Would you suggest staying on the 20mg a couple more days before going to the 10mg? Would it even help at this point? Would it mean I would have to be on 10mg more after?

Thanks