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Always love posts on research about potential causes

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Ulcerative Colitis
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Posted 4/2/2021 5:27 PM (GMT 0)
Sounds like MAP isn't the only smart, immune and antibiotic resistant strain that could be causational.



McMaster-led team unlocks possible Crohn’s disease trigger

https://brighterworld.mcmaster.ca/articles/mcmaster-led-team-unlocks-possible-crohns-disease-trigger/

Investigator Brian Coombes said his team identified a strain of adherent-invasive E-coli (AIEC) that is strongly implicated in the condition and is often found in the intestines of people with Crohn’s disease.

“If you examine the gut lining of patients with Crohn’s disease, you will find that around 70 to 80 per cent of them test positive for AIEC bacteria, but one of the things we don’t understand is why,” said Coombes, professor and chair of the Department of Biochemistry and Biomedical Sciences, and the Canada Research Chair in Infectious Disease Pathogenesis.

“We believe that AIEC is a potential trigger of Crohn’s disease.”

AIEC bacteria grow in a biofilm that coats cells lining the intestinal wall, protecting them from both the immune system and antibiotics. The team identified a critical protein structure on the surface of the bacteria that lets them grow in biofilms.
Posted 4/2/2021 11:59 PM (GMT 0)
I forget the name of the study, but they've been doing it for a few years now. In Crohn's patients, they inject them with inactivated e. coli bacteria and water, sort of like a vaccine. The body then mounts a defense against the e. coli in the bowel and the patient experiences reduced disease. Ugh... if I remember the study I'll post it. It's being spearheaded by Dr. Bressler in Canada.

They've suspected e. coli variants as being a cause of IBD for a long time, more so in CD, because e. coli is one of the only infectious bacteria that can actually change the shape of the bowel wall. In UC, there may be different agents. Dr. Borody in Australia who was the first to treat MAP with AMAT, thinks that UC is is due to fusobacteria, but he hasn't confirmed it yet.

Even if they aren't the root cause, eliminating these bacteria would probably help improve outcomes a lot. I know it has for me.
Posted 4/3/2021 3:14 AM (GMT 0)
......huge difference between using the word cause vs trigger regarding UC and CD.
The word used should be trigger.
q
Posted 4/3/2021 11:46 PM (GMT 0)
Here is an article "Beneficial modulation of the gut microbiota". I thought the info related to Inflammatory Bowel Disease was interesting.
https://www.sciencedirect.com/science/article/pii/S0014579314002543
I found this article when researching the BiomeFx test which does full genome sequencing of the GI microbiome unlike other tests that just use 16S. My husband is considering doing this test to help him get better control of his UC. You can find more information under the education section here: biomefx.com
What I liked about the test is the interpretation and recommendation guides are available to the patient and offers suggestions for lifestyle, diet, and supplements that can have a positive impact on your microbiome and hopefully in turn IBD. Let me know what you think?
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