Anyone else have symptoms return after only missing 1 or 2 doses of Xeljanz?

I had diarrhea again today with some very mild cramping. I did miss one Xeljanz pill yesterday and I think I missed one earlier in the week as well. I seem to get mild symptoms after only missing a dose or two. I just wondered if this was normal. It seems odd to me. I have a pill organizer which I've been trying to use and that helps but sometimes I still miss a dose or two here or there. It always feels like mild UC stuff. I'm not one to usually get these types of issues from certain foods. It seems tied to missing doses.

I'm due for my regular bloodwork and am going to try to get that done tonight while I'm at the hospital getting an ultrasound on my shin. I developed a strange indentation on my shin about 6 weeks ago that never fully goes away. No pain or discoloration. My PCP looked at it Monday and couldn't figure it out but said it's probably nothing but to get an ultrasound just to make sure. I can usually figure out all my weird medical issues on Google but this one I can't figure out.

Well, dang! You need to stop missing doses. Fate is going to get tired of you tempting it lol

I think there’s some stomach virus going around too that causes diarrhea and cramping. My son was sick a couple days 2 weeks ago but blamed it on his (lack of) gall bladder. His wife stayed home 2 days this week. I’ve had crampy days lately too.

Hopefully that’s what you experienced

Definitely focus on taking your meds and not missing any doses! This is so important when you have a chronic disease. I have aways been anal about taking my meds because I don’t want to flare but even with that level of commitment, it does not always work. Maybe add it to your daily to do list. I always have it written down in my journal and put a line through it after I take each medicine.
Aside from this, I have IBS in addition to UC so my poop varied a ton the entire time I was in remission. My scope was always good besides the lead pipe colon and IC valve erosion so my poop was never normal. I varied between diarrhea, very soft poop and constipation the whole time I was on Simponi. I rarely had “perfect poops” but I never did before my Uc diagnosis either. Also, having covid several times changed my poop and the smell permanently so that is also something to consider. All this to say that it may just be something you ate or stress or missing the dose. Just be as proactive as you can.

If I miss a pill i take double the next time (I'm on the 5mg dose so i figured it's not an overdose as some people take 10mg). Never missed more than one in a row though.

I wonder if you did pick up a bug. Granted the script sets out how to take it daily, I can't imagine missing 1-2 pills would upset the apple cart, just my thoughts. Does anyone know how long one dose stays in the system?

I hope you are better today.