Calorie Restriction *WITH OPTIMAL NUTRITION* is probably the best way, I have been donig CR for over 1 year. This means a diet which primarily consists of vegetables, some fruits, olive oil, nuts, seeds, oats (porridge), fish, beans etc...
Calorie Restriction Drastically Reduces Risk of Heart Attack, Stroke and Diabetes
http://mednewsarchive.wustl.edu/medadmin/PAnews.nsf/0/F76B2638BDB6CAE786256E76005D51F6
Strict diet lowers heart risk
http://www.bupa.co.uk/health_information/html/health_news/210404heart.html
Restriction of calorie intake slows down heart ageing
http://www.nutraingredients-usa.com/news/ng.asp?n=65136-mediterranean-diet-low-calorie
calorie restriction WILL lower your cholesterol to ranges of about
120-160mg/dl